Significances of urinary levels of ulinastatin in the diagnosis of dementia

尿乌司他丁水平在痴呆诊断中的意义

• 批准号: 05455013
• 负责人: TAKAORI Shuji
• 金额: $ 4.03万
• 依托单位: Shimane Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05455013/
• 关键词: Ulinastatin; alpha1-Microglobulin; Alzheimer-type senile dementia; Vascular dementia; Human urine; パーキンソン氏病; 精神分裂病; 気分障害患者

Relationships between urinary levels of alpha1-microglobulin (alpha1M) and ulinastatin (UT) in patients with dementia were investigated. There were no significant differences in alpha1M and UT levels and alpha1M/UT ratios among three groups : age-matched control subjects, patients with either Alzheimer-type senile dementia (ATD) and vascular dementia (VD). Although a positive correlation was established between alpha1M and UT levels in these groups, the regression slope of demented patients differed significantly from that of controls (P<0.05). A tendency toward a negative correlation between alpha1M/UT ratios and the scores of severity, or duration, of the disease was displayd in the ATD group, whereas a tendency toward a positive correlation between alpha1M/UT ratios and the scores of severity was observed in the VD group. In ATD patients, lower scores of severity were observed, where a lower alpha1M levels were registered. These results suggest that changes in the alpha1M levels and the relationships between urinary levels of alpha1M and UT may provide a useful biochemical index for the diagnosis of dementia.

目的探讨痴呆患者尿α 1-微球蛋白（α 1 M）与乌司他丁（UT）的关系。在年龄匹配的对照组、阿尔茨海默型老年痴呆（ATD）和血管性痴呆（VD）患者中，α 1 M和UT水平以及α 1 M/UT比值均无显著差异。虽然在这些组中α 1 M和UT水平之间建立了正相关，但痴呆患者的回归斜率与对照组相比差异显著（P<0.05）。在ATD组中，alpha 1 M/UT比值与疾病严重程度评分或持续时间呈负相关趋势，而在VD组中，alpha 1 M/UT比值与疾病严重程度评分呈正相关趋势。在ATD患者中，观察到较低的严重程度评分，其中记录了较低的alpha 1 M水平。提示尿α 1 M水平的变化及其与UT的关系可能为痴呆的诊断提供一个有用的生化指标。

项目成果

Inagaki,T.: "Changes in the ratio of urinary α1-microglobulin to ulinastatin levels in patients with dementia" Jpn.J.Psychiat.Neurol.(submitted).

Inagaki, T.：“痴呆患者尿 α1-微球蛋白与乌司他丁水平的比率变化”Jpn.J.Psychiat.Neurol.（已提交）。

Shikimi,T.: "Relationships between urinary levels of ulinastatin and α1-microglobulin and the severity of Alzheimer-type or vascular dementia" Jpn J Clin Pharmacol Ther. 24. 571-577 (1993)

Shikimi, T.：“乌司他丁和 α1-微球蛋白的尿水平与阿尔茨海默型或血管性痴呆的严重程度之间的关系”Jpn J Clin Pharmacol Ther 24. 571-577 (1993)

Shikimi,T.: "Effects of heparin on the inhibitory activities of human urinary trypsin inhibitor(ulinastatin)on trypsin,chymotrypsin and leukocyte elastase" Jpn J Pharmacol. 62. 115-118 (1993)

Shikimi，T.：“肝素对人尿胰蛋白酶抑制剂（乌司他丁）对胰蛋白酶、胰凝乳蛋白酶和白细胞弹性蛋白酶的抑制活性的影响”Jpn J Pharmacol。

Momiyama,T.: "Enhancement of D2 receptor agonist-induced inhibition by D1 receptor agonist in the ventral tegmental area" Br J Pharmacol. 110. 713-718 (1993)

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Inagaki T: "Changes in the ratio of urinary alpha1-microglobulin to ulinastatin levels in patients with dementia" Jpn.J.Psychiat.Neurol.(submitted).

Inagaki T：“痴呆患者尿 α1-微球蛋白与乌司他丁水平的比率变化”Jpn.J.Psychiat.Neurol.（已提交）。