A molecular hub regulating root stem cell replenishment in Arabidopsis

拟南芥根干细胞补充调节的分子中枢

• 批准号: 432468382
• 负责人: Professorin Dr. Yvonne Stahl
• 金额: --
• 依托单位: Institut für Molekulare Biowissenschaften
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/432468382?language=en
• 关键词: molecular; hub; regulating; root; stem

One of the most important questions in plant root development is how stem cell homeostasis is regulated in the root in response to the many different external and internal cues. The root’s stem cell pool has to be maintained and from time to time replenished by coordinated divisions of the quiescent center (QC) cells when stem cells are lost due to differentiation or different stresses, e.g. genotoxicity. A multitude of different factors such as phytohormones and transcriptional regulators are known to play important roles in regulating QC divisions, and therefore stem cell replenishment. Still, most of the interconnections of the many different factors are largely unknown. In this proposed project, we aim to scrutinize newly emerging links of some local and some more general regulators of stem cell replenishment. Furthermore, the localization of transcriptional regulators in differential sub-nuclear domains will be analyzed for their function in the necessary fine-tuned balance of stem cell maintenance and differentiation. Taken together, in this project we aim to uncover the highly interleaved regulation and interaction of different transcriptional regulators involved in root stem cell replenishment.

植物根发育中最重要的问题之一是根中干细胞的稳态是如何响应许多不同的外部和内部信号而调节的。根的干细胞库必须得到维持，并且当干细胞由于分化或不同的应激（例如遗传毒性）而丢失时，通过静止中心（QC）细胞的协调分裂不时地补充。许多不同的因素，如植物激素和转录调节因子，已知在调节QC分裂中发挥重要作用，因此干细胞补充。尽管如此，许多不同因素之间的相互联系在很大程度上还是未知的。在这个拟议的项目中，我们的目标是仔细检查一些地方和一些更一般的干细胞补充监管机构的新出现的联系。此外，本地化的转录调节在不同的亚核结构域将分析其功能，在必要的微调平衡的干细胞的维持和分化。总之，在这个项目中，我们的目标是揭示高度交错的调控和相互作用的不同转录调控参与根干细胞补充。