The effect of smoking on the development of lung cancer in idiopathic interstitial pneumonia

吸烟对特发性间质性肺炎肺癌发生的影响

• 批准号: 05670510
• 负责人: HOMMA Yukihiko
• 金额: $ 1.09万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670510/
• 关键词: Idiopathic interstilial pneumonia; Pulmonary fibrosis; Lung cancer; Growthfactor; Oncogene; 特発性間質性肺炎

The incidence lung cancer in 66 patients (54 males and 12 females), who were originally diagnosed as having idiopathic interstitial pneumonia (IIP), was studied prospectively by following them 2 to 13 years.As controls, sex and smoking history matched patients with chronic obstructive pulmonary disease (COPD) were also surveyed for the same follow up period.Eleven patients with IIP (16,7%) developed lung cancer.This incidence was significantly higher than that of COPD (1 out of 95,1%) group (p<0.01), regardless of the higher mean age and mean observation period of COPD group.All lung cancer patients except one were male smokers.In clinical findings, IIP patients with lung cancer didn't have steroid treatment and volume decrease in chest roentogenogaram when compared with those who did not develop lung cancer.In the immunohistochemical study, we examined the hypothesis that there is a paracrine mechanism of growth factor in the lung cancer with IIP.To validate it, we stained lung specimen with Epidermal growth factor (EGF) and EGF-receptor (EGF-R).Two of 9 IIP (+) patients and 23 of 44 IIP (-) patients showed positive for EGF staining.In stroma cells, 5 of 9 IIP (+) patients and 6 out of 44 IIP (-) patients exhibited positive for EGF straining (p<0.05).For EGF-R,there weren't any significant difference between the two groups.These results suggest that there might exist paracrine mechanism in the growth of lung cancer with IIP.

对最初诊断为特发性间质性肺炎 (IIP) 的 66 名患者（54 名男性和 12 名女性）进行了为期 2 至 13 年的前瞻性研究，对他们的肺癌发病率进行了前瞻性研究。作为对照，还对性别和吸烟史匹配的慢性阻塞性肺疾病 (COPD) 患者进行了同一随访期的调查。11 名 IIP 患者 (16.7%) 发展为肺癌。 无论 COPD 组的平均年龄和平均观察期较高，其发病率均显着高于 COPD（95.1% 中的 1 例）（p<0.01）。除 1 名肺癌患者外，所有肺癌患者均为男性吸烟者。在临床发现中，与未发展为肺癌的患者相比，患有肺癌的 IIP 患者未接受类固醇治疗且胸部 X 射线体积减少。在免疫组织化学研究中，我们检查了 假设 IIP 肺癌中存在生长因子的旁分泌机制。为了验证这一点，我们用表皮生长因子 (EGF) 和 EGF 受体 (EGF-R) 对肺标本进行染色。9 名 IIP (+) 患者中的 2 名和 44 名 IIP (-) 患者中的 23 名显示 EGF 染色阳性。在基质细胞中，9 名 IIP (+) 患者中的 5 名和 44 名 IIP 中的 6 名 (-)患者EGF应变呈阳性(p<0.05)。EGF-R两组间无显着差异。这些结果提示IIP肺癌的生长可能存在旁分泌机制。

项目成果

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