GENETIC BACKGROUND AND PREVENTION BY DUST MASK IN FARMER'S LUNG DISEASE(FLD)

农民肺病（FLD）的遗传背景和防尘口罩预防

• 批准号: 03670388
• 负责人: HOMMA Yukihiko
• 金额: $ 1.15万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670388/
• 关键词: FARMER'S LUNG DISEASE; HLA; FIELD SURVEY; IgA; MICROPOLYSPORA FAENI; Micropolyspora faeni; HLA

To investigate the genetic background and the way of prevention for farmer's lung disease(FLD), major histocompatibility complex(HLA A,B,C, DR,DQ), effectiveness of dust mask and serum specific IgA antibody were examined in dairy farmers with positive and negative serum specific IgG antibody and in the patients with FLD. Obtained results were as follows;1) No significant difference in all loci of HLA in each group.2) Newly developed small dust-proof mask with low inspiratory resistance was effective for prevention of FLD.3) Specific IgA antibody was found to be sensitive enough to detect antigen exposure and to be useful in differenciating asymptomatic patients from normal farmers.These results suggest that the monitoring of antigen exposure with serum antigen-specific IgA antibody and the application of dust mask may be useful for the prevention of FLD.

为探讨农民肺病（FLD）的遗传背景和防治方法，对血清特异性IgG抗体阳性和阴性的奶农及FLD患者进行了主要组织相容性复合体（HLA A、B、C、DR、DQ）、防尘口罩效果及血清特异性伊加抗体检测。获得的结果如下：结果表明：（1）各组间HLA各位点无显著性差异;（2）新研制的低吸气阻力小防尘口罩对预防FLD有效;（3）特异性伊加抗体检测抗原暴露敏感性高，可用于无症状患者与正常农民的鉴别。特异性伊加抗体的检测和防尘口罩的应用可能有助于预防FLD。