Epidemiologic and clinicopathologic study of presenile demented disorders

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In order to examine the demographic data of the patients with presenile dementia, the informations were obtained through questionnaires sent to 99 medical facilities, composed of 15 mental hospitals, and 96 hospitals and 88 clinics having Departments of psychiatry, neurology and neurosurgery. The objects were all the demented patients with the disease onset in the age of 30-64 years regardless of the cause. They had been the outpatients or inpatients during a month of Oct, 1995. The items of questionnaires were composed of sex, adress, age, duration, diagnosis, complications, severity and inheritance of dementia. As the result, the disorder of the highest incidence was Alzheimer's disease (AD), and the second was vascular dementia (VD). Other disorders included Pick's disease, progressive supranuclear palsy, alcholic dementia and brain injury, et al. Inheritance of dementia was found in 12% of the patients with AD.The patients with AD were usually severer than those with VD.The patients with alcohlic dementia had the high proportion of inpatients, although their severity of dementia was relatively mild. The epidemiologic study of presenile dementia is more difficult than that of senile dementia, because it includes various disorders, and has long duration of disease.