Epidemiologic and clinicopathologic study of presenile demented disorders

为了检查老年痴呆患者的人口统计学数据，通过向99个医疗机构发送问卷获得信息，其中包括15家精神病院，96家医院和88家诊所，设有精神科、神经科和神经外科。研究对象均为30-64岁起病的痴呆患者，不论病因为何。他们都是1995年10月的门诊或住院病人。问卷内容包括性别、住址、年龄、病程、诊断、并发症、严重程度、遗传等。结果表明，老年痴呆症发病率最高，其次为血管性痴呆。其他疾病包括Pick病、进行性核上性麻痹、酒精性痴呆和脑损伤等，其中12%的AD患者存在痴呆遗传，AD患者的痴呆程度通常较VD患者严重，酒精性痴呆患者住院比例较高，但痴呆程度相对较轻。早老性痴呆的流行病学研究比老年性痴呆困难，因为它包括多种疾病，而且病程长。

In order to examine the demographic data of the patients with presenile dementia, the informations were obtained through questionnaires sent to 99 medical facilities, composed of 15 mental hospitals, and 96 hospitals and 88 clinics having Departments of psychiatry, neurology and neurosurgery. The objects were all the demented patients with the disease onset in the age of 30-64 years regardless of the cause. They had been the outpatients or inpatients during a month of Oct, 1995. The items of questionnaires were composed of sex, adress, age, duration, diagnosis, complications, severity and inheritance of dementia. As the result, the disorder of the highest incidence was Alzheimer's disease (AD), and the second was vascular dementia (VD). Other disorders included Pick's disease, progressive supranuclear palsy, alcholic dementia and brain injury, et al. Inheritance of dementia was found in 12% of the patients with AD.The patients with AD were usually severer than those with VD.The patients with alcohlic dementia had the high proportion of inpatients, although their severity of dementia was relatively mild. The epidemiologic study of presenile dementia is more difficult than that of senile dementia, because it includes various disorders, and has long duration of disease.