The Study concerning the pathogenesis of non-Alzheimer neurodegenerative dementias from the perspective of abnormal cytoskeletons

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The study concerning the pathogenesis of non-Alzheimer neurodegenerative dementias has been performed from the perspective of abnormal cytoskeletons. Cytopathological and clinicopathological studies of dementia with Lewy bodies (DLB) have been focused. In the cytopathological studies, formation process or degeneration process of Lewy bodies was investigated using α-synuclein immunohistochemistry. Lewy bodies were formed by the accumulation of α-synuclein in the abnormal cytoskeletons with axonal transport blockage, and degenerated with glial and immunological reaction. In the clinicopathological studies, Lewy pathology was graded from stage I to stage IV, and autopsied cases of DLB were classified into some subtypes according to the degree of Lewy pathology or Alzheimer pathology. In frontotemporal dementia (FTD), Pick's disease (PiD) was divided into two types of tauopathy and ubiquitinopathy.