Molecular biological study of lymphocytic stem cell leukemia

淋巴细胞干细胞白血病的分子生物学研究

基本信息

  • 批准号:
    05670937
  • 负责人:
  • 金额:
    $ 0.83万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 财政年份:
    1993
  • 资助国家:
    日本
  • 起止时间:
    1993 至 1994
  • 项目状态:
    已结题

项目摘要

We analyzed the immunoassociated genes, specially T-cell receptor(TcR)delta chain gene, of sixteen patients with CD7+stem cell leukemia as lymphocytic stem cell leukemia, and of nine patients with sinonasal malignant lymphoma.In 1993, we reported that the DDJdelta rearrangement are frequently shown in the patients with CD7+ stem cell leukemia and occur more earlier stage than that of expression of cytoplasmic CD3epsilon in T-cell development. These findings indicate DDJdelta to be a marker of T-lineage stem cell, and suggest that TcRdelta gene rearrangement occur as following ; DD*DDJ*VDDJ.In 1994, we documented that five out of sixteen patients with CD7+ stem cell leukemia, showed the specific clinical, immunophenotypic and immunogenotypic characteristics. We reported this subgroup as T-precursor leukemia/lumphoma. The T-precursor leukemia/lymphoma has some characteristics as following ; 1) on phenotypic examination, the phenotypes of blast cells correspond to those of early T cells between prothymocyte stage I and II,2) on the clinical feature at diagnosis, without blast cells in peripheral blood, with thymoma (4/5 cases) and lymphoadenopaty (4/5 cases) ; these patients achieved complete remission (5/5) but had relapse (4/5) , indicating transformation to mixed type (4/4, T/B/M-2 cases, T/M-2 cases) , 3) on immunogenotypic examination, the presence of the common Ddelta2 (D) Jdelta1. The more intensive chemotherapy including the stem cell transplantation should be considered to alter the poor prognosis of T-precursor leukemia.In nine patients with sinonasal malignant lymphoma, which is generally considered to be T-cell lineage, 8 cases were suggested to be originated from Natural killer (NK) cell, which in many patients correspond to fetal NK cell type with cCD3. This finding suggests the presence of common precursor to both NK cell and T-cell. The lymphoma cells of all nine patients have the monoclonal integration of Epstein Barr virus.
我们分析了16例CD7+干细胞白血病(淋巴细胞干细胞白血病)和9例鼻窦恶性淋巴瘤患者的免疫相关基因,特别是t细胞受体(TcR) δ链基因。在1993年,我们报道了DDJdelta重排在CD7+干细胞白血病患者中经常出现,并且在t细胞发育中比细胞质CD3epsilon的表达更早发生。这些发现表明DDJdelta是t系干细胞的标记物,并提示TcRdelta基因重排发生如下:DD *以* VDDJ。1994年,我们报道了16例CD7+干细胞白血病患者中有5例表现出特定的临床、免疫表型和免疫基因型特征。我们报道这个亚群为t前体白血病/淋巴瘤。t前体白血病/淋巴瘤具有以下特点:1)表型检查,母细胞表型与胸腺原细胞I期和II期早期T细胞表型一致;2)诊断时临床特征,外周血无母细胞,有胸腺瘤(4/5)和淋巴腺瘤(4/5);这些患者完全缓解(5/5),但复发(4/5),表明转化为混合型(4/4,T/B/M-2病例,T/M-2病例),3)免疫基因型检查,存在常见的Ddelta2 (D) Jdelta1。应考虑加强包括干细胞移植在内的化疗,以改变t前体细胞白血病的不良预后。在9例通常被认为是t细胞谱系的鼻窦恶性淋巴瘤中,8例被认为是来自自然杀伤(NK)细胞,在许多患者中,NK细胞与胎儿NK细胞类型相对应。这一发现表明NK细胞和t细胞存在共同的前体。9例患者的淋巴瘤细胞均含有eb病毒单克隆整合体。

项目成果

期刊论文数量(64)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
K Akashi,et al.: "T lymphoid/myeloid bilineal crisis in chronic myelogenous leukemia" Experimental Hematology. 21. 743-748 (1993)
K Akashi 等人:“慢性粒细胞白血病中的 T 淋巴/骨髓双系危机”实验血液学。
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    0
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J Suzumiya,et al.: "Expression of adult and fetal natural killer cell markers in sinonasal lvmphomas" Blood. 4月号発表予定. (1994)
J Suzumiya 等人:“鼻腔淋巴结肿大中成人和胎儿自然杀伤细胞标记物的表达”计划于 4 月号出版(1994 年)。
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    0
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Akashi K. , Mizuno S. , Harada M. , Kimura N. et al. :"T lymphoid/myeloid bilineal crisis in chronic myelogenous leukemia" Exp. Hematol.21. 743-748 (1993)
明石 K.、水野 S.、原田 M.、木村 N. 等。
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    0
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Kimura N. , Akiyoshi T. , Uchida T et al.: "High prevalence of T-cell receptor Ddelta2 (Ddelta) Jdelta rearrangement in CD7-positive stem cell leukemia/lymphoma" submitting to Leukemia.
Kimura N.、Akiyoshi T.、Uchida T 等人:“CD7 阳性干细胞白血病/淋巴瘤中 T 细胞受体 Ddelta2 (Ddelta) Jdelta 重排的高发生率”提交给白血病。
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  • 影响因子:
    0
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Ohshima K., Kikuchi M., Kobari S., Masuda Y., Eguchi F., Kimura N.: "Amplified bcl-2/JH rearrangements in reactive lymphoadenopathy" Virchows Archiv (B) : Cell Pathology. 63. 197-198 (1993)
Ohshima K.、Kikuchi M.、Kobari S.、Masuda Y.、Eguchi F.、Kimura N.:“反应性淋巴结病中放大的 bcl-2/JH 重排” Virchows Archive (B):细胞病理学。
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    0
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KIMURA Nobuhiro其他文献

Image analysis for velocity profile estimation in A-SOFT hybrid rocket combustor
A-SOFT 混合火箭燃烧室速度剖面估计的图像分析
  • DOI:
    10.1299/jfst.2018jfst0029
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0.8
  • 作者:
    KIMURA Nobuhiro;OBATA Kei;KITAGAWA Koki;SHIMADA Toru
  • 通讯作者:
    SHIMADA Toru

KIMURA Nobuhiro的其他文献

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{{ truncateString('KIMURA Nobuhiro', 18)}}的其他基金

A study of the boiling phenomena with the enhanced heat transfer in superfluid helium under microgravity condition
微重力条件下超流氦强化传热沸腾现象研究
  • 批准号:
    22360361
  • 财政年份:
    2010
  • 资助金额:
    $ 0.83万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Clarification of the emphasis effect of the heat transfer which was observed around λ pressure in superfluid helium, and its applications
阐明超流氦中λ压力附近传热的强调效应及其应用
  • 批准号:
    18360410
  • 财政年份:
    2006
  • 资助金额:
    $ 0.83万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
An application of the heat transfer enhancement effect of the self-induced vibration of superfluid helium to the space observation enquipment
超流氦自激振动强化传热效应在空间观测设备中的应用
  • 批准号:
    14550857
  • 财政年份:
    2002
  • 资助金额:
    $ 0.83万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis of T-cell clone indicating GVL effect due to allo stem cell transplantation and donor lymphocytes infusion.
T 细胞克隆分析表明同种异体干细胞移植和供体淋巴细胞输注产生 GVL 效应。
  • 批准号:
    10670975
  • 财政年份:
    1998
  • 资助金额:
    $ 0.83万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Analysis of T-cell receptor genes in malignant lymphocytic disease ; Rearrangement of TcR delta chain gene.
恶性淋巴细胞疾病中T细胞受体基因分析;
  • 批准号:
    63570579
  • 财政年份:
    1988
  • 资助金额:
    $ 0.83万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
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