Analysis of T-cell receptor genes in malignant lymphocytic disease ; Rearrangement of TcR delta chain gene.
恶性淋巴细胞疾病中T细胞受体基因分析;
基本信息
- 批准号:63570579
- 负责人:
- 金额:$ 1.28万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1988
- 资助国家:日本
- 起止时间:1988 至 1989
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We analyzed the rearrangement of T-cell receptor(TcR) delta chain gene, reported as fourth TcR gene, in malignant lymphoproliferative disorders. All of 9 acute lymphoblastic leukemias/lymphoblastic lymphomas(ALL/LBL), of which 4 cases have neither beta nor gamma gene rearrangement, had a new rearranged band of TcR delta locus. Of B-ALL/LBL 41% had rearranged band(s) and of that 23% showed the deletion of TcR delta locus. The VD or DD rearrangement in B-lineage and DD, DJ or VDJ in T- lineage ALL/LBL are suggested due to the results of the delta gene rearrangement pattern. The frequency of the new rearranged band(s) and deletion of the delta locus was 10% and 40% in T-lymphomas, 7% and 9% in B-lymphomas, 20% and 40% in AILDs, and 7% and 7% in acute myelocytic leukemias(AML). Any cases with Hodgkin's disease and adult T-cell leukemia/lymphoma(ATL/ATLL) did not have a new rearranged band of delta locus. The frequency of the delta deletion in those diseases were 61% and 83%. It is suggested that ATL/ATLL, T-lymphoma and a part of Hodgkin's disease and AILD are originated from alpha beta-T-cell. Appearance of delta rearranged band in B-lymphoma and AML are suggested as a missprogram of those tumor cells. The analysis of delta chain gene in T-cell lines show that there is pre-alpha beta T-cell subclass in alpha beta T-lineage.Finally, these studies suggest that 1) the delta chain gene rearranges at a very early stage of the T-cell differentiation, prior to the other TcR genes. 2) delta gene analysis is an useful tool to evaluate clonality, particularly for the most immature T-cell leukemia/lymphoma with no lineage-associated markers or rearrangement of the other TcR genes. 3) rearrangement of TcR delta is not lineage specific but useful in evaluating lymphold lineage of ALL/LBL, when used in conjunction with the immunoglobulin heavy chain gene.
我们分析了T细胞受体(TcR)δ链基因重排,报告的第四TcR基因,在恶性淋巴组织增生性疾病。9例急性淋巴细胞白血病/淋巴母细胞淋巴瘤(ALL/LBL)TcR δ基因重排均出现一条新的重排带,其中4例既无β基因重排,也无γ基因重排。在B-ALL/LBL中,41%有重排带,其中23%有TcR δ位点缺失。根据δ基因重排模式的结果,提出B系可能存在VD或DD重排,T系可能存在DD、DJ或VDJ重排。新重排条带和δ位点缺失的频率在T淋巴瘤中为10%和40%,在B淋巴瘤中为7%和9%,在AILD中为20%和40%,在急性髓细胞白血病(AML)中为7%和7%。任何霍奇金病和成人T细胞白血病/淋巴瘤(ATL/ATLL)病例均未出现新的δ基因重排带。δ缺失率分别为61%和83%。提示ATL/ATLL、T淋巴瘤、部分霍奇金病和AILD均起源于α β T细胞。在B淋巴瘤和AML中出现δ重排带,提示这两种肿瘤细胞可能存在错配。对T细胞系δ链基因的分析表明,在α β T细胞系中存在前α β T细胞亚群,并提示:(1)δ链基因在T细胞分化的早期就发生重排,先于其它TcR基因; 2)δ基因分析是评估克隆性的有用工具,特别是对于没有谱系相关标记或其他TcR基因重排的最不成熟T细胞白血病/淋巴瘤。3)TcR δ重排不是谱系特异性的,但当与免疫球蛋白重链基因结合使用时,可用于评估ALL/LBL的淋巴细胞谱系。
项目成果
期刊论文数量(28)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
木村暢宏 その他: "分子遺伝学的な高悪性度リンパ腫の診断ー危険因子としての二重遺伝子型とMaltiple再構成バンド" 日本綱内系学会雑誌. 29. 321-327 (1989)
Nobuhiro Kimura 等:“高级别淋巴瘤的分子遗传学诊断 - 双基因型和多重重排带作为危险因素”日本内科学会杂志 29. 321-327 (1989)。
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N. Kimura et al.: "Diagnosis of high risk lymphoma by molecular genotypic analysis ; Bigenotype and multiple rearranged bands as risk factor." J Jpn Soc R.E.S. 29(4):321-327, 1989.
N. Kimura 等人:“通过分子基因型分析诊断高危淋巴瘤;双基因型和多个重排带作为危险因素。”
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木村暢宏、他: "分子遺伝学的な高悪性度リンパ腫の診断ー急険因子としての二重遺伝子型とMultiple再構成バンド" 日本網内系学会雑誌. 29. 321-327 (1989)
Nobuhiro Kimura 等人:“高级别淋巴瘤的分子遗传学诊断 - 双基因型和多重重排带作为危险因素”日本网状内皮系统学会杂志 29. 321-327 (1989)。
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Nobuhiro Kimura et al.: "Rearrangement of T-cell receptor δ chain gene as marker of lineage and clonality in T cell lymphoproliferative disorders." Cancer Research. 49. 4488-4492 (1989)
Nobuhiro Kimura 等人:“T 细胞受体 δ 链基因的重排作为 T 细胞淋巴增殖性疾病的谱系和克隆性标记。”49. 4488-4492 (1989)。
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N. Uike et al.: "Dual rearrangement of immunoglobulin and T-cell receptor genes in blast crisis of CML." Eur J Haematol 42:460-465, 1989.
N. Uike 等人:“CML 急变期免疫球蛋白和 T 细胞受体基因的双重重排。”
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KIMURA Nobuhiro其他文献
Image analysis for velocity profile estimation in A-SOFT hybrid rocket combustor
A-SOFT 混合火箭燃烧室速度剖面估计的图像分析
- DOI:
10.1299/jfst.2018jfst0029 - 发表时间:
2018 - 期刊:
- 影响因子:0.8
- 作者:
KIMURA Nobuhiro;OBATA Kei;KITAGAWA Koki;SHIMADA Toru - 通讯作者:
SHIMADA Toru
KIMURA Nobuhiro的其他文献
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{{ truncateString('KIMURA Nobuhiro', 18)}}的其他基金
A study of the boiling phenomena with the enhanced heat transfer in superfluid helium under microgravity condition
微重力条件下超流氦强化传热沸腾现象研究
- 批准号:
22360361 - 财政年份:2010
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Clarification of the emphasis effect of the heat transfer which was observed around λ pressure in superfluid helium, and its applications
阐明超流氦中λ压力附近传热的强调效应及其应用
- 批准号:
18360410 - 财政年份:2006
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
An application of the heat transfer enhancement effect of the self-induced vibration of superfluid helium to the space observation enquipment
超流氦自激振动强化传热效应在空间观测设备中的应用
- 批准号:
14550857 - 财政年份:2002
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of T-cell clone indicating GVL effect due to allo stem cell transplantation and donor lymphocytes infusion.
T 细胞克隆分析表明同种异体干细胞移植和供体淋巴细胞输注产生 GVL 效应。
- 批准号:
10670975 - 财政年份:1998
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular biological study of lymphocytic stem cell leukemia
淋巴细胞干细胞白血病的分子生物学研究
- 批准号:
05670937 - 财政年份:1993
- 资助金额:
$ 1.28万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)