Study on hemocompatibility and antithrombotic characeristics of the small caliver vascular prosthesis

本研究的目的是评价纤维连接蛋白、胶原和胰岛素共价固定对小口径人造血管的早期通畅性、血液相容性和愈合的影响。将6个纤维连接蛋白、胶原和胰岛素涂覆的ePTFE移植物和6个未处理的ePTFE移植物植入6只杂种犬的颈动脉中。移植物原纤维长30 μ m，直径4mm。分别于植入后1天、7天、4周、16周进行观察。共价移植物的通畅率为66%，未处理移植物的通畅率为75%。两组间无显著性差异。但纤维连接蛋白、胶原和胰岛素共价移植物在吻合口附近表现出纤维化改变和平滑肌细胞增殖。总之，结果表明，纤维连接蛋白，胶原蛋白和胰岛素的共价接枝是有益的，促进骨折愈合，并没有减少抗血栓形成。

The objective of this study was to evaluate the effects of fibronectin, collagen and insulin covalent immobilization on early patency, hemocompatibility and healing of small caliber vascular prostheses. Six fibronectin, collagen and insulin coated ePTFE grafts and six untreated ePTFE grafts were implanted into the carotid artery in 6 mongrel dogs. The grafts were 30micrometer in fibril length, 4mm in diameter. Observation was performed at 1day, 7day, 4week, 16week after implantation. The patency rates of the grafts were 66% for covalent graft and 75% for untreated graft. There was no significant difference among the two groups. But fibronectin, collagen and insulin covalent grafts demonstrated fibroplastic change and proliferation of smooth muscle cells near the anastomotic sites. In conclusion, the results suggest that fibronectin, collagen and insulin covalent grafts is useful for promoting fraft healing, and does not diminish anti thrombogenecity.