Study on hemocompatibility and antithrombotic characeristics of the small caliver vascular prosthesis

小口径人工血管血液相容性及抗血栓特性研究

• 批准号: 05670980
• 负责人: SAKUMA Makoto
• 金额: $ 1.28万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670980/
• 关键词: vascular prosthesis; hemocompatibilitiy; antithrombotic property; fibronectin; collagen coated graft; Vascular Prosthesis; anticoagulability; blood compatibility; arterial reconstruction; oPTFE; 人工血管(Vascular graft); 抗血栓(anti-thrombogenecity) /

The objective of this study was to evaluate the effects of fibronectin, collagen and insulin covalent immobilization on early patency, hemocompatibility and healing of small caliber vascular prostheses. Six fibronectin, collagen and insulin coated ePTFE grafts and six untreated ePTFE grafts were implanted into the carotid artery in 6 mongrel dogs. The grafts were 30micrometer in fibril length, 4mm in diameter. Observation was performed at 1day, 7day, 4week, 16week after implantation. The patency rates of the grafts were 66% for covalent graft and 75% for untreated graft. There was no significant difference among the two groups. But fibronectin, collagen and insulin covalent grafts demonstrated fibroplastic change and proliferation of smooth muscle cells near the anastomotic sites. In conclusion, the results suggest that fibronectin, collagen and insulin covalent grafts is useful for promoting fraft healing, and does not diminish anti thrombogenecity.

本研究的目的是评价纤维连接蛋白、胶原和胰岛素共价固定对小口径人造血管的早期通畅性、血液相容性和愈合的影响。将6个纤维连接蛋白、胶原和胰岛素涂覆的ePTFE移植物和6个未处理的ePTFE移植物植入6只杂种犬的颈动脉中。移植物原纤维长30 μ m，直径4mm。分别于植入后1天、7天、4周、16周进行观察。共价移植物的通畅率为66%，未处理移植物的通畅率为75%。两组间无显著性差异。但纤维连接蛋白、胶原和胰岛素共价移植物在吻合口附近表现出纤维化改变和平滑肌细胞增殖。总之，结果表明，纤维连接蛋白，胶原蛋白和胰岛素的共价接枝是有益的，促进骨折愈合，并没有减少抗血栓形成。

项目成果

平野 聡: "新しい小口径人工血管の開発-多孔質含フッ素エラストーマ人工血管" 日本血管外科学会雑誌. 4(発表予定). (1995)

Satoshi Hirano：“新型小直径人造血管——多孔含氟弹性体人造血管的开发”，日本血管外科学会杂志4（待发表）。

西部 俊哉: "多孔質セグメント化ポリウレタン人工血管の長期移植成績" 日本血管外科学会雑誌. 4. 643-649 (1995)

Toshiya Nishi：“多孔分段聚氨酯人工血管的长期植入结果”日本血管外科学会杂志 4. 643-649 (1995)。

佐久間 まこと: "高度の虚血性心疾患を合併するFontaine IV度症例に対するバイパス術" 血管外科. 12. 40-44 (1993)

Makoto Sakuma：“Fontaine IV 病例并发严重缺血性心脏病的搭桥手术”，《血管外科》，12. 40-44 (1993)。

NISHIBE,T.: "Effects of fibronectin covalent immobilization on early patency and graft healing of small caliber expanded Polytetrafluoroethylene grafts." Jpn.J.Vasc.Surg.5. 177-182 (1996)

NISHIBE,T.：“纤连蛋白共价固定对小口径膨胀聚四氟乙烯移植物早期通畅和移植物愈合的影响。”

NISHIBE,T.: "Long term results of an experimental study of small caliber segmentedpolyurethane grafts." Jpn.J.Vasc.Surg.4. 643-649 (1996)

NISHIBE,T.：“小口径分段聚氨酯接枝物实验研究的长期结果。”