Study on dental alloys to clarify the mechanism of allergy

研究牙科合金以阐明过敏机制

• 批准号: 05671631
• 负责人: FURUKAWA Kazutoshi
• 金额: $ 1.34万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671631/
• 关键词: Metal Allergy; Functional Measurement of Electrode Potential; Penetration of Metallic Ions; 歯科用合金

In order to clarify the mechanism of allergy, functional measurements of the electrode potential within the oral cavity were undertaken. This method involved measuring the metallic ion penetration of the various dental alloys within the oral cavity. The alloys measured were Co, Cr, Ni, and Sn which are considered to be dental materials having a high allergy rate, and were in turn compared to the low allergy rate dental alloys of Au and Au-Ag-Pd. The experiment involved 4 male subjects having either a full cast crown on the premolar or molar region. The functional condition included 3 type of measurements, 1) during the rest position, 2) lateral movement, and 3) with a pH3.75 solution in the mouth. Results showed that for Ni-Cr alloy, the electric potential changed from -63.9--325.7mV during rest position, -82.0--365.3mV during lateral movement, and -92.4--396.7mV with the solution. For Co-Cr alloy, the electric potential changed from -134.3--4.115mV during rest position, -181.7--434.0mV during lateral movement, and -279.3--427.7mV with the solution. Ag alloy showed the electric potential to change from -154.8--288.4mV during rest position, -191.2--308.7mV during lateral movement, and -234.2--376.8mV with the solution. The electric potential for Au-Ag-Pd alloy changed from +51.4--135.0mV during rest position, +51.8--138.3mV during lateral movement, and -27.0--238.4mV with the solution. For Au alloy, the electric potential changed from +25.0--103.9mV during rest position, +21.4--132.0mV during lateral movement, and -35.6--226.2mV with the solution . In conclusion, it can be said that the functional measurments of electrode potential for the dental materials showed penetration of metallic ions.

为了阐明过敏的机制，进行了口腔内电极电位的功能测量。该方法涉及测量口腔内各种牙科合金的金属离子渗透。所测量的合金是Co、Cr、Ni和Sn，它们被认为是具有高过敏率的牙科材料，并且依次与低过敏率牙科合金Au和Au-Ag-Pd进行比较。该实验涉及4名男性受试者，其在前磨牙或磨牙区域上具有全铸造牙冠。功能条件包括3种类型的测量，1）在休息位置期间，2）侧向运动，和3）口腔中pH 3.75溶液。结果表明，镍铬合金在静止位时电位变化范围为-63.9--325.7mV，在侧向运动时为-82.0--365.3mV，在溶液中为-92.4--396.7mV。钴铬合金在静止位时电位变化范围为-134.3--4.115mV，在侧向运动时电位变化范围为-181.7--434.0mV，在溶液中电位变化范围为-279.3--427.7mV。银合金在静息位电位为-154.8--288.4mV，在侧移位电位为-191.2--308.7mV，在溶液中电位为-234.2--376.8mV。金-银-钯合金的电位在静止位时为+51.4--135.0mV，在侧向运动时为+51.8--138.3mV，在溶液中为-27.0--238.4mV。对于Au合金，在静止位置时电位变化为+25.0--103.9mV，在侧向运动时为+21.4--132.0mV，在溶液中为-35.6--226.2mV。总之，可以说牙科材料的电极电位的功能测量显示金属离子的渗透。

项目成果

松田もと子: "パッチテストによる皮膚反応の色彩学的分析" 日本補綴歯科学会雑誌. 38. 588-595 (1994)

Motoko Matsuda：“通过斑贴试验进行皮肤反应的色彩分析”日本修复医学会杂志 38. 588-595 (1994)。

Motoko Matsuda, et al: "Colormetric Analysis of the Skin Reaction by Patch Test" J,Jpn Prosthodont Soc. 38. 588-595 (1994)

Motoko Matsuda 等人：“通过斑贴试验对皮肤反应进行比色分析”J，Jpn Prosthodont Soc。