The effects of oral potassium and magnesium supplementation on blood pressure and the serum lipid level in humans

本研究的目的是研究口服镁（Mg）对血压（BP）和相关因素（如尿儿茶酚胺）和脂质代谢的影响。在第一项研究（13名健康的年轻受试者）中，进行了双盲交叉研究（研究一），而第二项研究由30名老年受试者（研究二）组成。在研究1中，受试者分别服用对照饮食（Ca: 500， Mg 250mg/天）并口服安慰剂（p期），以及在对照饮食（Mg期）中口服氢氧化镁（Mg: 393-471mg/天），为期10天。尿Mg排泄量在Mg期明显增加，而收缩压和舒张压在p- Mg期之间没有变化。与p期相比，Mg期尿去甲肾上腺素排泄量（UNE）下降了12%，而其他相关变量在补充Mg期间没有变化。24日尿Mg排泄量增加至p期2倍的受试者，Mg期的UNE和BP下降更为明显。在给药期间，LCAT也显著升高，但高密度脂蛋白胆固醇、总胆固醇和甘油三酯均保持不变。在研究ii中，收缩压和舒张压在mg期明显降低，而在p期没有。与对照组相比，mg期血浆醛固酮浓度和红细胞压积显著升高。从对照组到mg期，UNE的%变化与舒张压的%变化之间也存在显著的正相关。尿钾排泄量与UNE呈正相关。补充Mg后，观察到LCAT， hdl -胆固醇和载脂蛋白ai有统计学意义的增加。因此，这些结果表明，补充Mg可能通过尿钠和抑制UNE释放来降低血压，并通过激活LCAT来改善人体脂质水平。少

The aim of this study is to examine the effects of oral magnesium (Mg) supplementation on blood pressure (BP) and related factors, such as urinary catecholamine, and the lipid metabolism. In the first study (13 healthy young subjects), a double-blind, crossover study was performed (Study-I) while the second study consisted of 30 elderly subjects (Study-II). In study I, the subjects consumed a control-diet (Ca : 500, Mg 250mg/day) with oral supplementation of a placebo (P-period), and the oral supplementation of Mg-hydroxide (Mg : 393-471mg/day) with the control diet (Mg-period) for 10 days, respectively. The urinary Mg excretion significantly increased during the Mg-period, while the systolic and diastolic BP did not change between the p- and Mg-periods. The urinary norepinephrine excretion (UNE) decreased 12% during the Mg-period compared to the P-period, whereas the other related variables did not change during Mg supplementation. In addition, the UNE and BP during the Mg-period sign … More ificantly decreased in the subjects whose 24-hurinary Mg excretion increased to twice that in the P-period. The LCAT also significantly increased during the Mg-period, but the HDL-cholesterol, total-cholesterol and triglyceride all remained unchanged. In studyII, the systolic and diastolic BP significantly decreased during the Mg-period, but not in the P-period. The plasma aldosterone concentration and hematocrit significantly increased in the Mg-period compared to the control period. There was also a significant positive correlation between the %-change from the control to the Mg-period of the UNE and that of the diastolic BP.However, the urinary K excretion positively correlated with the UNE.A statistically significant increase in the LCAT, HDL-cholesterol and apo-AI was observed after Mg supplementation. These results therefore suggest that Mg supplementation may both lower the BP through natriuresis and the suppression of UNE release, and improve the lipid levels through the activatation of LCAT in humans. Less