The differences between the effects of oral potassium supplementation and magnesium supplementation on blood pressure and lipid metabolism in human subjects.

口服补钾和补充镁对人体血压和脂质代谢影响的差异。

• 批准号: 08680051
• 负责人: ITOH Kazue
• 金额: $ 1.41万
• 依托单位: Nakamura Gakuen University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08680051/
• 关键词: Potassium; Mgnesium; Blood Pressure; Lipid Metabolism; Human; Oral; LCAT; Catecholamine; アルドステロン; カテコールアミン

The aim of this study was to examine the differences between the effects of potassium (K) supplementation and magnesium (mg) supplementation on both blood pressure and lipid metabolism. In the first study (consisting of 20 healthy yound subjects), a cross-over study was performaed (Study I), while the second study consisting of 13 elderly subjects (study II). In study I,the subjects consumed a control diet (K 2g, Mg 250mg/day) with oral supplementation and all thus received oral Mg supplementation (Mg-load : Mg 411mg/day) and K supplementation (K-load : K 1.9g/day) afor 4 weeks, respectively. The subjects in study II received the same protocol as that in study I.The sysotolic blood pressure values significanlty decrased after the K-load. A significantly negative correlation was observed between the urinary K excretion and sodium excretion (both expressed as a precentage of the run-in value) on the K-load. In the Mg-loas, there was a statistically significant negative correlation between the values for urinary noradrenaline excretion and urinary Mg excretion (expressed as a percentage of teh run-in value). The systolinc blood pressure also significantly decreased due to a reduction of the 24h-noradrenaline excretion. A statistically significant increase in LCAT was also observed after Mg supplementation. A significantly posotive correlation was observed between the levels of LCAT and HDL in the Mg-load, but this did not occur in the K-load. These results suggest that the Mg-load may lower blood pressure by suppressing the adregergic activity and also by possibly inducing natriuresis, while the K-load may decrease blood pressure through natriuresis. In addition, the serum lipid also improved through the activation of lCAT in human subjects after an Mg-load.

本研究的目的是探讨补充钾 (K) 和补充镁 (mg) 对血压和脂质代谢的影响之间的差异。在第一项研究（由 20 名健康青年受试者组成）中，进行了一项交叉研究（研究 I），而第二项研究由 13 名老年受试者组成（研究 II）。在研究 I 中，受试者食用对照饮食（钾 2g，镁 250 毫克/天）并口服补充剂，因此所有人分别接受口服镁补充剂（镁负荷：镁 411 毫克/天）和钾补充剂（钾负荷：钾 1.9 克/天）4 周。研究II中的受试者接受与研究I相同的方案。K负荷后收缩压值显着下降。尿钾排泄量和钠排泄量（均以磨合值的百分比表示）与钾负荷之间存在显着负相关。在镁-洛阿中，尿去甲肾上腺素排泄值和尿镁排泄值（以磨合值的百分比表示）之间存在统计学上显着的负相关性。由于24小时去甲肾上腺素排泄减少，收缩压也显着降低。补充镁后，还观察到 LCAT 显着增加。在镁负荷中观察到 LCAT 和 HDL 水平之间存在显着的正相关性，但在钾负荷中并未出现这种情况。这些结果表明，镁负荷可以通过抑制降压活性以及可能诱导尿钠排泄来降低血压，而钾负荷可以通过尿钠排泄来降低血压。此外，人类受试者在镁负荷后，通过激活 lCAT 也可改善血脂。

项目成果

Itoh K,Kawasaki T,Nakamura M.: "The effects of high oral magnesium supplementation on blood pressure, serum lipids and related variables in apparenetly healthy Japanese subjects" British Journal of Nutrition. 78. 737-750 (1997)

Itoh K、Kawasaki T、Nakamura M.：“高口服镁补充剂对表面健康的日本受试者的血压、血脂和相关变量的影响”英国营养学杂志。