Formation od lipid membranes in organic solutions and their functionalization

有机溶液中脂质膜的形成及其功能化

• 批准号: 05680510
• 负责人: IHARA Hirotaka
• 金额: $ 1.28万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05680510/
• 关键词: lipid membranes; molecular membranes; supramolecular assemblies; amino acid; enantioselectivity; membrane permeation; circular dichloism; photo-induced polymerization; 相分離; 光学活性; ゲル; 光応答性; 不斉; 配向; 重合性脂質

In this study, special lipids having an aromatic head group and two long-chain alkyl group have been synthesized from L-glutamic acid and their aggregation behavior in organic solutions has been investigated. The results can be summarized as follows :1) Only the lipids into which the head and alkyl groups were introduced through amide binding can form highly-oriented structures in benzene solutions. The computer calculation indicated that the three amide bonding per molecule provide effective intermolecular hydrogen bonding among lipids.2) The lipid with a sorbyl group as a head group was synthesized. This lipid produced highly-oriented structure in ethanol. The uv-irradiation induced intermolecular condensation between sorbyl groups.3) The selective elution behavior of amino acid-derivatives was also examined using these highly-oriented aggregates in benzene solutions. When the lipid with a pyridinium-head group was mixed in the aggregates, effective enantioselectivity was observed. DSC and CD studies indicate that the selectivity is performed through the phase separation of pyridinium-containing lipids.

本研究以L-谷氨酸为原料，合成了一种具有芳香族头基和两个长链烷基的特殊脂质，并研究了其在有机溶液中的聚集行为。结果表明：1）只有通过酰胺键引入了头部和烷基的脂质在苯溶液中才能形成高度取向的结构。计算机计算表明，每个分子中的三个酰胺键提供了有效的分子间氢键。2）合成了以山梨糖醇为头基的脂质。这种脂质在乙醇中产生高度取向的结构。紫外光照射诱导山梨糖醇基团之间的分子间缩合。3）利用这些高度取向的聚集体在苯溶液中研究了氨基酸衍生物的选择性洗脱行为。当与吡啶鎓头基团的脂质混合在聚集体中，观察到有效的对映选择性。DSC和CD研究表明，选择性是通过含吡啶的脂质的相分离来进行的。

项目成果

伊原 博隆: "配向性分子材料の機能設計と用途新展開" アイ・ピ-・シ-, 300 (1995)

Hirotaka Ihara：“定向分子材料的功能设计和新应用开发”IPC，300（1995）

伊原 博隆: "Chirally arranged monomeric dyes on helical bilayer membranes." Liquid Crystals. 13. 307-311 (1993)

Hirotaka Ihara：“螺旋双层膜上的手性排列单体染料。”13. 307-311 (1993)

伊原 博隆: "脂質膜類似物によるオルガノゲルの形成と分子認識への応用" 表面. 32. 43-54 (1994)

Hirotaka Ihara：“使用脂质膜类似物形成有机凝胶及其在分子识别中的应用”Surface 32. 43-54 (1994)。

Makoto Takafuji, Hirotaka Ihara, Chuichi Hirayama, Hiroshi Hachisako, and Kimiho Yamada: "Functional organic gels. Chirality induction though formation of highly-oriented structures" Liquid Crystals. Vol.18. 97-99 (1995)

Makoto Takafuji、Hirotaka Ihara、Chuichi Hirayama、Hiroshi Hachisako 和 Kimiho Yamada：“功能性有机凝胶。通过形成高度定向结构进行手性感应”液晶。

伊原博隆: "脂質膜類似物によるオルガノゲルの形成と分子認識への応用" 表面. 32. 43-54 (1994)

Hirotaka Ihara：“使用脂质膜类似物形成有机凝胶及其在分子识别中的应用”Surface 32. 43-54 (1994)。