Formation od lipid membranes in organic solutions and their functionalization

点击翻译按钮获取中文摘要

In this study, special lipids having an aromatic head group and two long-chain alkyl group have been synthesized from L-glutamic acid and their aggregation behavior in organic solutions has been investigated. The results can be summarized as follows :1) Only the lipids into which the head and alkyl groups were introduced through amide binding can form highly-oriented structures in benzene solutions. The computer calculation indicated that the three amide bonding per molecule provide effective intermolecular hydrogen bonding among lipids.2) The lipid with a sorbyl group as a head group was synthesized. This lipid produced highly-oriented structure in ethanol. The uv-irradiation induced intermolecular condensation between sorbyl groups.3) The selective elution behavior of amino acid-derivatives was also examined using these highly-oriented aggregates in benzene solutions. When the lipid with a pyridinium-head group was mixed in the aggregates, effective enantioselectivity was observed. DSC and CD studies indicate that the selectivity is performed through the phase separation of pyridinium-containing lipids.