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High-selective HPLC with chiral organogels

使用手性有机凝胶的高选择性 HPLC

基本信息

批准号：
14350446
负责人：
IHARA Hirotaka
金额：
$ 8.7万
依托单位：
Kumamoto University (2002, 2004)Kyushu University (2003)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

Recently, organogel systems have been attractive. This is due to the facts that they can be produced through three-dimensional fibrous network formation with low-molecular compounds although conventional hydrogels are mostly produced by partial crosslinking of amorphous polymers. Therefore, organogel systems are often accompanied by supramolecualr functions such as enhancement of chirality. However, there are some distinct disadvantages compared with hydrogel systems. The most serious problem is due to the fact that organogels are mechanically fragile. Therefore, we have tried to polymerize organogels to extend their possible applications. In this study, we have focused on application of organogel systems for HPLC separation by stabilization of organogels. For this purpose, we designed (1)novel organogel-forming lipophilic compounds (lipids) and their physicochemical properties such as chirality and ordered structures were investigated. Also stabilization of organogels was carried out by (2)photo-induced polymerization of the polymerizable lipids prepared in this study and (3)radical polymerization ofa bulk solution with the non-polymerizable lipids. Also (4)HPLC separation has carried out with the chiral lipid-immobilized silica as packing materials and molecular-shape selectivity and chiral recognition ability were discussed with aromatic hydrocarbons as samples.

近年来，有机凝胶体系越来越受到人们的关注。这是因为它们可以通过与低分子化合物形成三维纤维网络来产生，尽管传统的水凝胶大多是通过无定形聚合物的部分交联来产生的。因此，有机凝胶体系往往伴随着手性增强等超分子功能。然而，与水凝胶系统相比，它有一些明显的缺点。最严重的问题是有机凝胶在机械上是易碎的。因此，我们尝试聚合有机凝胶以扩大其可能的应用范围。在这项研究中，我们重点研究了有机凝胶体系在通过稳定有机凝胶进行高效液相分离中的应用。为此，我们设计了(1)新型形成有机凝胶的亲脂化合物，并研究了它们的手性和有序结构等物理化学性质。此外，有机凝胶的稳定化也是通过(2)本研究制备的可聚合脂类的光诱导聚合和(3)与不可聚合脂类的本体溶液的自由基聚合来实现的。(4)以手性脂类固定化二氧化硅为填充物进行了高效液相色谱分离，并以芳香烃为样品，探讨了其分子形态选择性和手性识别能力。