Pathology platform for heart and lung tissue and Liquid Biobanking

点击翻译按钮获取中文摘要

For the second funding period of KFO we (Hannover Unified Biobank - HUB and the working group Jonigk of the Institute of Pathology of the MHH) will benefit from many years of experience inbiomaterial collection and preservation (tissues, cells, microorganisms and body fluids) as well as our histopathological and molecular pathological expertise from routine work and heart and lung Research in translation from "bench to bed". This includes an established and unique infrastructure for the rapid processing of fresh human tissue and body fluids, as well as biobanking, long-term storage and the provision of existing networks and expertise. In addition, through our histopathological and molecular expertise we will support KFO-researchers in analyzing human and animal tissue samples generated from experiments. We are thus generating readily available, expertassessed and extremely valuable tissues from human and animal hearts and lungs, as well as standardized fluid samples. This will add value to KFO and the related research groups. All existing KFO samples are stored in a standardized and quality-assured way. Additional, new biomaterials will be generated: i) HUB with approx. 2,000 serum and plasma samples per year and one EDTA buffy coat per patient, ii) Pathology with approx. 2,700 compartment-specific reprocessed tissue samples (per LVAD implantation approx. 10 samples, per heart explant about 60 samples). To provide a comprehensive overview of available samples and sample quality for KFO researchers, a sample platform (interface between CentraXXand PathoPro) will be implemented, in which all KFO samples are visible. From this sample platform, sample data will be periodically transmitted to the KFO database (Filemaker).