Experimental study on endovascular therapy for aortic dissection

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We investigated a new device of endovascular therapy for aortic dissection using a canine aortic dissection model.1) Aortic dissection model : We created bypass channel in the descendingaorta of a mongrel dogusing a prosthetic tube graft. We evaluated patency of bypass channel as false lumen 2 and 4 weeks after the procedure.2) Device ; The device was designed and made to close directly the entry of aortic dissection. It consists a balloon and a patch. The balloon can permanently maintain its inflated shape with solidifying liquids (HEMA).3) Experiment ; We testedour device in aortic dissection model. It was impossible to insert the device through catheter, so we place the device through the aortotomy in the descending aorta. On angiographic evaluation 2 weeks later, bypass channel was closed. It suggested the efficacy of our device. However, balloon was broken one month later and bypasses channel was patent.4) Conclusion ; We aimed to develop a new device for endovascular therapy of aortic dissection. The efficacy of our new device was suggested through the experiment. Further improvement of the device and an animal model of aortic dissection were needed.