Experimental study on endovascular therapy for aortic dissection

主动脉夹层腔内治疗的实验研究

• 批准号: 06454395
• 负责人: TABAYASHI Koichi
• 金额: $ 3.2万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454395/
• 关键词: Aortic dissection; Entry; endovascular; Treatment; 血管内エントリ-閉鎖; カテーテル治療

We investigated a new device of endovascular therapy for aortic dissection using a canine aortic dissection model.1) Aortic dissection model : We created bypass channel in the descendingaorta of a mongrel dogusing a prosthetic tube graft. We evaluated patency of bypass channel as false lumen 2 and 4 weeks after the procedure.2) Device ; The device was designed and made to close directly the entry of aortic dissection. It consists a balloon and a patch. The balloon can permanently maintain its inflated shape with solidifying liquids (HEMA).3) Experiment ; We testedour device in aortic dissection model. It was impossible to insert the device through catheter, so we place the device through the aortotomy in the descending aorta. On angiographic evaluation 2 weeks later, bypass channel was closed. It suggested the efficacy of our device. However, balloon was broken one month later and bypasses channel was patent.4) Conclusion ; We aimed to develop a new device for endovascular therapy of aortic dissection. The efficacy of our new device was suggested through the experiment. Further improvement of the device and an animal model of aortic dissection were needed.

1）主动脉夹层模型：在杂种犬的降主动脉内建立旁路通道。术后2周和4周评价旁路通道作为假腔的通畅性。2）器械;该器械设计和制造用于直接关闭主动脉夹层的入口。它由一个气球和一个补丁组成。3）实验：在主动脉夹层模型上对该装置进行了实验研究。无法通过导管插入器械，因此我们将器械通过降主动脉切开术置入。在2周后的血管造影评估中，旁路通道关闭。这表明了我们设备的功效。然而，球囊在一个月后破裂，旁路通道通畅。4）结论：我们旨在开发一种用于主动脉夹层血管内治疗的新器械。通过实验表明了我们的新装置的有效性。需要进一步改进装置和主动脉夹层动物模型。