Experimental studies on laser inner ear surgery

激光内耳手术的实验研究

• 批准号: 06454492
• 负责人: NOMURA Yasuya
• 金额: $ 3.07万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454492/
• 关键词: argon laser; semicircular canal; partitioning; surgical treatment; vertigo; めまい治療

This study is to elucidate effects of argon laser irradiation to the semicircular canals of guinea pigs on caloric response and morphological changes. After deep anesthesia using Nembutal, the bulla of the guinea pig was opened and semicircular canals were exposed.A probe was approached to the semicircular canals. Distance from the tip of the probe to the semicircular canal was less than 1 mm. The bony surface of the canals was irradiated by argon laser (1.0-1.5w, 0.5sec) several times along contour of the canals. Several weeks after irradiation, ice-water caloric test was performed using electronystagmography. Morphology of the inner ear was also investigated. EEG demonstrated that some animals lost caloric response with ice-water stimulation. Surface of the irradiated canals showed charred areas. Lumen of the canal was fibrous and/or ossified depending on duration of post-operative days.Sensory cells of the crista ampullaris were missing, even the ampullae were not irradiated. The cochlea was free from pathological changes, indicating that the argon laser irradiation was effective to abolish function of the canals with preservation of hearing.

本研究旨在探讨氩激光照射豚鼠半规管对热反应和形态学的影响。麻醉后，打开大泡，暴露半规管，用探针探入半规管。用氩激光（1.0-1.5w，0.5sec）沿半规管轮廓照射骨表面沿着。照射后数周，用眼震电图进行冰水冷热试验。还研究了内耳的形态。脑电图显示部分动物对冰水刺激失去热反应。照射后根管表面出现烧焦区。根据术后时间长短，管腔纤维化和/或骨化，壶腹嵴感觉细胞缺失，甚至壶腹也未照射。耳蜗无病理改变，表明氩激光照射能有效地消除耳道功能，并保留听力。

项目成果

Nomura Y.,Ooki S.,Kukita N.,Young Y.-H.: "Laser Labyrinthectomy" Acta Otolaryngol (Stockh). 115. 158-161 (1995)

Nomura Y.、Ooki S.、Kukita N.、Young Y.-H.：“激光迷路切除术”Acta Otolaryngol (Stockh)。

野村 恭也: "レーザー内耳手術" 第24回日本医学会総会会誌. II. 412-413 (1995)

Kyoya Nomura：“激光内耳外科”日本医学会第 24 届大会杂志 II 412-413。

Nomura Y, Ooki S, Kukita N, Young Y-H: "Laser Labyrinthectomy" Acta Otolaryngol (Stockh). 158-161 (1995)

Nomura Y、Ooki S、Kukita N、Young Y-H：“激光迷路切除术”Acta Otolaryngol (Stockh)。

Nomura Y: "Inner Ear Laser surgery" Proceeding of the 24^<th> General Assembly of The Japan Medical CongressII. 115. 412-413 (1995)

野村Y：《内耳激光手术》第24届日本医学会大会论文集II。

Nomura Y, Ooki S, Kukita N, Young Y-H: "Laser Labyrinthectomy" Acta Otolaryngol (Stockh). 115. 158-161 (1995)

Nomura Y、Ooki S、Kukita N、Young Y-H：“激光迷路切除术”Acta Otolaryngol (Stockh)。