An epidemiologic study on risk factors of oral precancers-Case control syudy-

许多研究表明，血清中高水平的β-胡萝卜素对口腔癌的发生有保护作用。然而，这种联系在口腔癌前病变的文献中还没有很好的记录。因此，这项研究的目的是显示血清类胡萝卜素水平与日本某城市日本居民口腔癌前病变发生的关系。来自同一人群的29名居民(试验组)在每年的健康筛查中被发现有口腔病变，3274名居民和120名没有口腔病变的居民(年龄和性别匹配的对照组)被纳入研究。试验组为男性白斑12例，女性扁平苔藓17例。两组均采静脉血进行血清分析，发现男性白斑患者血清角黄质和隐黄质水平明显低于对照组(p&lt；0.05)。然而，女性扁平苔藓患者的任何血清营养水平都没有显著差异。在吸烟习惯、饮酒习惯等其他项目上，未发现病变与对照组之间的特定相关性。

Many studies have shown that high serum levels of beta carotene has a protective effect against the occurence of oral cancer. However, such association has not been well-documented in the literature for oral precancers. It is thus the purpose of this study to show the relationship between serum carotenoid levels and the occurrence of oral precancerous lesions in Japanese residents of a city in Japan. Twenty-nine residents who were found to have oral lesions (test group) during an annual health screening of 3,274 residents and 120 residents with no lesions (age and sex-matched control group) from the same population were included in the study. The test group consist of 12 men with leukoplakia, 17 women with lichen planus. Venous blood samples were taken from all the residents in the test and control groups for serum analysis.The serum levels of canthaxanthin and cryptoxanthin was found to be significantly lower in male leukoplakia patients as compared with the control patients (p<0.05). However.there was no siginificant difference in any of the serum nutrient levels in female lichen planus patients. With regard of other items such as smoking habit, alcohol habits ets., no specific corelation between the lesions and the controls were found.