An epidemiologic study on risk factors of oral precancers-Case control syudy-

口腔癌前病变危险因素流行病学研究-病例对照研究-

• 批准号: 06454577
• 负责人: IKEDA Noriaki
• 金额: $ 1.73万
• 依托单位: AICHIGAKUIN-UNIVERSITY SCHOOL OF DENTISTRY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454577/
• 关键词: beta-carotene; leukoplakia; oral lichen planus; epidemiology; 扁平苔癬; 偏平苔癬

Many studies have shown that high serum levels of beta carotene has a protective effect against the occurence of oral cancer. However, such association has not been well-documented in the literature for oral precancers. It is thus the purpose of this study to show the relationship between serum carotenoid levels and the occurrence of oral precancerous lesions in Japanese residents of a city in Japan. Twenty-nine residents who were found to have oral lesions (test group) during an annual health screening of 3,274 residents and 120 residents with no lesions (age and sex-matched control group) from the same population were included in the study. The test group consist of 12 men with leukoplakia, 17 women with lichen planus. Venous blood samples were taken from all the residents in the test and control groups for serum analysis.The serum levels of canthaxanthin and cryptoxanthin was found to be significantly lower in male leukoplakia patients as compared with the control patients (p<0.05). However.there was no siginificant difference in any of the serum nutrient levels in female lichen planus patients. With regard of other items such as smoking habit, alcohol habits ets., no specific corelation between the lesions and the controls were found.

许多研究表明，高水平的β-胡萝卜素对口腔癌的发生有保护作用。然而，这种关联在口腔癌前病变的文献中并没有很好的记录。因此，本研究的目的是显示血清类胡萝卜素水平和口腔癌前病变的发生在日本的一个城市的日本居民之间的关系。在对3，274名居民进行年度健康筛查期间发现有口腔病变的29名居民（试验组）和来自同一人群的120名无病变居民（年龄和性别匹配的对照组）被纳入研究。实验组包括12名男性白斑患者和17名女性扁平苔藓患者。结果发现，男性白斑患者血清中隐黄质和黄黄素含量均显著低于对照组（P<0.05）。而女性扁平苔藓患者的血清营养素水平无显著性差异。至于其他项目，如吸烟习惯，饮酒习惯等，未发现病变与对照之间的特异性相关性。

项目成果

P.SHANMUHASUNTHARAM: "Serum concentrations of alpha-carotene,beta-carotene,Retinol and alpha-tocophenol in Malaysian patients with oral premalignant and malignant lesions." ORAL CANCER. 15-18 (1995)

P.SHANMUHASUNTHARAM：“马来西亚口腔癌前病变和恶性病变患者的 α-胡萝卜素、β-胡萝卜素、视黄醇和 α-生育酚的血清浓度。”

P.SHANMUHASUNTHARAM et al.: "Serum concentrations of alpha-carotene, beta caroten Retinol and alpha-tocophenol in Malaysian patients with oral premalignant and malignant lesions" ORAL CANCER. 15-18 (1995)

P.SHANMUHASUNTHARAM 等人：“马来西亚口腔癌前病变和恶性病变患者的 α-胡萝卜素、β-胡萝卜素、视黄醇和 α-生育酚的血清浓度”口腔癌。

P SHANMUHASUNTHARAM et al.: "Serum concentrations of alpha-carotene, betacarotene, Retinol and alpha-tocophenol in Malaysian patients with oral premalignant and malignant lesions." Oral Cancer. 15-18 (1995)

P SHANMUHASUNTHARAM 等人：“马来西亚口腔癌前病变和恶性病变患者的 α-胡萝卜素、β-胡萝卜素、视黄醇和 α-生育酚的血清浓度。”