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Effects of midazolam and flumazenilon autonomic nervous activities

咪达唑仑和氟马西隆自主神经活动的影响

基本信息

批准号：
06454576
负责人：
NOGUCHI Izumi
金额：
$ 4.1万
依托单位：
Tsurumi University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454576/
关键词：
flumazenil midazolam RR intervals maximum entropy method cutaneous blood flow tonometry blood pressure power spectral analysis Mem Calc スペクトルアレイ最大エレトロピー法トノメトリー血圧 Mem Calc

项目摘要

The effect of midazolam and flumazenil on depression of autonomic nervous activities were studied using power spectral analysis of fluctuations in heart rate, cutaneous blood flow and tonometry blood pressure.Healthy young male volunteers participated in two different sessions ; Group M received 0.07 mg/kg of midazolam only, and in Group MFmz, flumazenil 0.3 mg was administered 18 min after the injection of the same dose of midazolam. RR interval was recorded with SRR-5 (GMS Co.), and blood flow at the dorsum manus was measured with a laser doppler flowmeter AFL2 (Advance Co.). The successive analogue data were inputted via an A/D converter into a computer PC-9801BA2 (NEC Co.), and data were divided into subseries of 60 sec. Tonometry blood pressure were recorded with Jentow 7700 (Nihon-Khorin Co.) and analyzed by Autonomic Nervous System Package (Nihon-Khorin Co.). Analysis was carried out by the maximum entropy method (MEM) using MemCalc system (Suwa Trust Co.). Power spectrum densities were separated into four components (0.04-0.4Hz) in RR intervals and tonometry blood pressure, and into six (0.04-2.2Hz) in blood flow.The powers of 0.04-0.4Hz in RR intervals decreased to 27-50% (mean) of the basline value at 5 min in both groups. In Group MFmz, the decreased powers increased to 127-150% at 20 min. As to blood flow, powers of 0.1-0.20Hz decreased to 26-77% of the basline value at 5 min in both groups. In Group MFmz both values increased at 20 min. The same trend was obsewrved in tonometry blood pressure.It is indicated that midazolam depresses mainly the powers of low frequency, which means it depresses sympathetic nervous activity more than parasympathetic activity, and flumazenil antagonizes the depression.

采用心率、皮肤血流量和血压的功率谱分析方法，研究了咪达唑仑和氟马西尼对自主神经活动的抑制作用。M组仅接受0.07 mg/kg咪达唑仑，MFmz组，在注射相同剂量的咪达唑仑后18分钟给予氟马西尼0.3 mg。用SRR-5（GMS Co.）记录RR间期，用激光多普勒流量计AFL 2（Advance Co.）测量手背的血流量。通过A/D转换器将连续的模拟数据输入计算机PC-9801 BA 2（NEC Co.），并将数据分成60秒的亚系列。采用日本Khorin公司生产的Jentow 7700型血压计测量血压。并通过自主神经系统软件包（Nihon-Khorin Co.）进行分析。使用MemCalc系统（Suwa Trust Co.）通过最大熵法（MEM）进行分析。RR间期和血压的功率谱密度分为4个分量（0.04-0.4Hz），血流的功率谱密度分为6个分量（0.04-2.2Hz），两组RR间期0.04-0.4Hz的功率在5 min时均降至基线值的27-50%（平均值）。MFmz组20 min时功率下降127-150%，而0.1-0.20Hz组5 min时功率下降26-77%。MFmz组20 min时两值均升高，眼压也有相同趋势，提示咪达唑仑主要抑制低频功率，即对交感神经活性的抑制作用大于副交感神经活性，而氟马西尼可拮抗这种抑制作用。