Study on sedation using dexmedetomidine-Evaluation by EEG Entropy^<TM>

研究了镇静剂量的丙泊酚（Prop）和右美托咪定（Dex）对脑电图（BIS 和熵^<TM>）以及心肺变化的影响。还评估了EntropyTM(SE，RE)的特征。 12 名年轻男性志愿者参加了两个不同的疗程：P 组接受 Prop（8mg/kg/hr）10 分钟，然后 4mg/kg/hr 20 分钟，D 组接受 Dex（6μg/kg/hr）10 分钟，然后 0.2μg/kg/hr 20 分钟。每种药物在前 30 分钟内注射，并在前 10 至 20 分钟内施加刺激。测量BIS、SE、RE、Ramsay评分、健忘症、心率、血压、Spo2、呼吸频率和Etco2直至120分钟。输注期间，两组的 BIS·SE 和 RE 均下降。当给予刺激时，两组的BIS、SE和RE值均增加。拉姆齐评分增加并观察到健忘症。 P组心率增加、血压下降，D组心率下降。P组Spo2短暂下降，但Etco2和RR无变化。 D组Spo2短暂下降，Etco2下降，RR无变化。恢复期间，D组各项参数恢复到控制值的速度较P组慢。比较BIS与SE时，两组BIS与SE均存在相关性。 BIS 和 SE 也与 Ramsay 分数相关。输注过程中P组相关系数高于D组。从这项研究来看，接受Dex的患者很容易被催眠的刺激惊醒，需要较长的时间才能从镇静中恢复，并表现出轻微的心肺抑制作用。 BIS 和Entropy^<TM> 之间存在相关性。这两个值也与镇静水平相关，与 Dex 相比，Prop 的相关性更高。

The effects of sedative doses of propofol (Prop) and dexmedetomidine (Dex) on EEG (BIS and Entropy^<TM>), and cardiorespiratory changes were studied. The characteristics of Entropy^<TM>(SE, RE) were also evaluated. Twelve young male volunteers participated in two different sessions : Group P received Prop (8mg/kg/hr) for 10 min followed by 4mg/kg/hr for 20 min and Group D received Dex (6μg/kg/hr) for 10 min followed by 0.2μ g/kg/hr for 20 min. Each drug was injected for the first 30 min and stimulation by scaling was applied from the first 10 to 20 min. BIS, SE, RE, Ramsay score, amnesia, heart rate, blood pressure, Spo2, respiratory rate and Etco2 were measured until 120min. During infusion, BIS・SE and RE decreased in both groups. When stimulation was given, the value of BIS, SE and RE of both groups increased. Ramsay score increased and amnesia was observed. The increase of heart rate and decrease of blood pressure were observed in Group P, and decrease of heart rate was observed in Group D. In Group P, Spo2 decreased transiently, but Etco2 and RR showed no change. In Group D, Spo2 decreased transiently, Etco2 decreased, and RR showed no change. During recovery period, the values of all parameters of Group D returned to control values more slowly than those of Group P. When comparing BIS with SE, there was a correlation between BIS and SE in both groups. Both BIS and SE were also correlated with Ramsay scores. The correlation coefficient was higher in Group P than in Group D during infusion. From this study, patients receiving Dex are readily awakened by stimulation from hypnosis, and need longer time to recover from sedation, and showed slight cardiorespiratory depression effects. There is a correlation between BIS and Entropy^<TM>. Both values also correlate with sedation level with higher correlation in Prop compared to Dex.