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Study on sedation using dexmedetomidine-Evaluation by EEG Entropy^<TM>

右美托咪定镇静研究-脑电熵评价^<TM>

基本信息

批准号：
17592115
负责人：
NOGUCHI Izumi
金额：
$ 2.24万
依托单位：
Tsurumi University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

The effects of sedative doses of propofol (Prop) and dexmedetomidine (Dex) on EEG (BIS and Entropy^<TM>), and cardiorespiratory changes were studied. The characteristics of Entropy^<TM>(SE, RE) were also evaluated. Twelve young male volunteers participated in two different sessions : Group P received Prop (8mg/kg/hr) for 10 min followed by 4mg/kg/hr for 20 min and Group D received Dex (6μg/kg/hr) for 10 min followed by 0.2μ g/kg/hr for 20 min. Each drug was injected for the first 30 min and stimulation by scaling was applied from the first 10 to 20 min. BIS, SE, RE, Ramsay score, amnesia, heart rate, blood pressure, Spo2, respiratory rate and Etco2 were measured until 120min. During infusion, BIS・SE and RE decreased in both groups. When stimulation was given, the value of BIS, SE and RE of both groups increased. Ramsay score increased and amnesia was observed. The increase of heart rate and decrease of blood pressure were observed in Group P, and decrease of heart rate was observed in Group D. In Group P, Spo2 decreased transiently, but Etco2 and RR showed no change. In Group D, Spo2 decreased transiently, Etco2 decreased, and RR showed no change. During recovery period, the values of all parameters of Group D returned to control values more slowly than those of Group P. When comparing BIS with SE, there was a correlation between BIS and SE in both groups. Both BIS and SE were also correlated with Ramsay scores. The correlation coefficient was higher in Group P than in Group D during infusion. From this study, patients receiving Dex are readily awakened by stimulation from hypnosis, and need longer time to recover from sedation, and showed slight cardiorespiratory depression effects. There is a correlation between BIS and Entropy^<TM>. Both values also correlate with sedation level with higher correlation in Prop compared to Dex.

本文观察了异丙酚（Prop）和右美托咪定（Dex）镇静剂量对脑电（BIS）和熵谱（Entropy<TM>）及心肺功能的影响。还<TM>评估了熵^（SE，RE）的特性。12名年轻男性志愿者参加了两次不同的会议：P组接受Prop D组先用地塞米松（8 mg/kg/hr）10 min，再用地塞米松（4 mg/kg/hr）20 min每种药物在前30分钟注射，从前10分钟到20分钟通过缩放施加刺激。BIS，SE，记录RE、Ramsay评分、遗忘、心率、血压、Spo 2、呼吸频率和Etco 2，直至120 min。输注过程中两组BIS·SE、RE均下降。刺激后两组BIS、SE、RE值均升高。Ramsay评分增加，并观察到健忘症。P组心率增快、血压下降，D组心率减慢。P组Spo 2一过性降低，而Etco 2和RR无变化。D组Spo 2一过性降低，Etco 2降低，RR无变化。恢复期D组各项指标恢复至对照值的速度均慢于P组。BIS与SE比较，两组BIS与SE之间存在相关性。BIS和SE也与Ramsay评分相关。在输注过程中，P组的相关系数高于D组。从这项研究来看，接受Dex的患者很容易被催眠的刺激唤醒，需要更长的时间从镇静中恢复，并表现出轻微的心肺抑制作用。BIS和熵之间存在相关性<TM>。这两个值也与镇静水平相关，与Dex相比，Prop的相关性更高。