The effects of isoflurane anesthesia on serum myoglobin, CPK and electrolytes

异氟烷麻醉对血清肌红蛋白、CPK、电解质的影响

• 批准号: 03670964
• 负责人: NOGUCHI Izumi
• 金额: $ 1.41万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670964/
• 关键词: Isoflurane; Serum myoglobin; CPK; Serum electrolytes; Pediatric anestehsia; Na^+; K^+; Ca^<++>; 血清ミオグロビン値; CPK値; RIA法

The effect of isoflurane on the increase in serum myoglobin (Mb) and creatinekinase (CK) levels induced by Sch was studied. 78 children were divided into four groups ; in the two groups (Group IV, IM), the induction and maintenance was achieved with N20, 02 and isoflurane, and in the last two groups (Group HV, HM) halothane was administered instead of isoflurane. After loss of consciousness, they were injected with Sch 1mg/kg intravenously in Group IV and IH, and 2mg/kg intramusculaly in Group IM and IH to facilitate tracheal intubation. Blood samples were drawn till 60 min. Mb was determined by the radioimmunoassay and CK was by the modified Rosalki's method. AS a result, Mb values increased from 5 min in all groups, and CK values increased from 5 min in Group IV and HV, and at 60 min in Group IM and HM. The value in Group IV at 60 min was 120 times higher than the control data in Mb, and 5 times in CK, respectively. The values in Group IM and HM were less than Group IV and HV, and the delays in increases were noted. There was not a significant difference in the values between Group IV and HV, or Group IM and HM. K^+ value increased remarkably in Group IM and HM till 20 min, and decreased in Group IV and HV at 60 min. Inorganic phosphate increased at 5min in Group IV and HM, and decreased in Group HV, IM and IM at 60min. Na^+ and Ca^<2+> decreased from 5 min, and the decreases lasted till 60 min. No correlationship was occurred in increases in Mb and K values. It is indicated that we should be cautious to avoid myoglobinemia or possibly malignant hyperthermia, during isoflurane anesthesia.

本文观察了异氟醚对Sch引起的血清肌红蛋白（Mb）和肌酸激酶（CK）升高的影响。将78名儿童分为四组;在两组（IV组，IM）中，用N20、02和异氟烷实现诱导和维持，并且在最后两组（HV组，HM）中，施用氟烷而不是异氟烷。意识丧失后，IV组和IH组静注Sch 1 mg/kg，IM组和IH组肌注Sch 2 mg/kg，协助气管插管。采用放射免疫法测定Mb，改良Rosalki法测定CK。结果，Mb值在所有组中从5 min开始升高，CK值在IV组和HV组中从5 min开始升高，在IM组和HM组中从60 min开始升高。60 min时，组IV的Mb值是对照值的120倍，CK值是对照值的5倍。IM组和HM组的值低于IV组和HV组，并且观察到增加延迟。IV组和HV组或IM组和HM组之间的值无显著差异。K^+值IM组和HM组在20 min时显著升高，IV组和HV组在60 min时显著降低。无机磷在IV组和HM组在5 min时升高，HV组、IM组和IM组在60 min时显著降低。Na^+和Ca^<2+>从5 min开始下降，并持续到60 min，Mb和K值的增加无相关性。提示异氟醚麻醉时应注意避免肌红蛋白血症或可能的恶性高热。

项目成果

I NOGUCHI, M Andou H Sankawa, Y AMEMIYA: "Effects of Isoflurane Anesthesia on Serum Levels of Myoglobin, CK in Children - Changes Induced by Succinylcholine Injected Intravenously or Intramuscularly" Masui. Vol.42. (1993)

I NOGUCHI、M Andou H Sankawa、Y AMEMIYA：“异氟醚麻醉对儿童肌红蛋白、CK 血清水平的影响 - 静脉或肌内注射琥珀胆碱引起的变化”Masui。