Transcriptional regulation proteins of human ATP synthae subunit b gene

人ATP合成亚基b基因的转录调控蛋白

• 批准号: 06454656
• 负责人: HIGUTI Tomihiko
• 金额: $ 4.03万
• 依托单位: Faculty of Pharmaceutical Sciences, The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454656/
• 关键词: ATP synthase; subunit b; transcriptional regulation; Aging; enhancer; biogenesis; mitochondria; 形態形成; ヒト遺伝子; subunit b遺伝子; Sp1; BTEB; エンハンサー45K; エンハンサー70K

We have obtained the following three important scientific findings.1. The stoichiometry of mRNAs of ATP synthase in rat tissues determined with synthesized mRNAs and probe cDNAs2. Similarlity of the transcriptional regulation system of subunit b and e genes of ATP synthase3. Novel nuclear proteins bound to the enhancer cis-element in the first intron of subunit b gene1) Four kinds of nuclear proteins were bound to the enhancer cis-element in the first intron of subunit b gene : Sp1, BTEB,and novel 45kD and 70kD nuclear proteins.

我们得到了以下三个重要的科学发现。用合成mrna和探针cDNAs2测定大鼠组织中ATP合酶mrna的化学计量学。ATP合成酶3亚基b和e基因转录调控系统的相似性。b亚基基因第一个内含子增强子顺式元件结合的新型核蛋白1)b亚基基因第一个内含子增强子顺式元件结合的核蛋白有Sp1、BTEB和新型45kD和70kD核蛋白。

项目成果

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