Breaking selective constraints: is Hsp90 a capacitor of evolutionary change?

打破选择性限制：Hsp90 是进化变化的电容器吗？

• 批准号: DP0557494
• 负责人: Prof Carla Sgro
• 金额: $ 47.57万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-10-31 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0557494
• 关键词: Breaking; selective; constraints; Hsp90; capacitor

Gene action and expression can be modulated by genetic mechanisms. If a general mechanism controlling gene expression exists that can be easily manipulated it has the potential to allow animal and plant breeders to quickly produce and select for new characters of agricultural importance without relying on transgenics and long-term breeding programs. It would also assist in the development of tools for identifying and detecting genes that increase susceptibility to human diseases, such as cancer, that are only expressed under certain conditions environmental. I intend to determine whether the protein Hsp90 represents a general mechanism controlling gene expression.

基因的作用和表达可以通过遗传机制来调节。如果存在一种控制基因表达的通用机制，并且可以很容易地操纵，那么它就有可能使动植物育种家在不依赖转基因和长期育种计划的情况下，快速生产和选择具有农业重要性的新性状。它还将有助于开发工具，以确定和检测只在某些环境条件下表达的增加对人类疾病（如癌症）易感性的基因。我打算确定Hsp90蛋白是否代表控制基因表达的一般机制。