Experimental test of the consequences of host-parasite co-evolution

宿主-寄生虫共同进化后果的实验测试

• 批准号: 43577956
• 负责人: Professor Dr. Hinrich Schulenburg
• 金额: --
• 依托单位: Arbeitsgruppe Evolutionsökologie und Genetik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/43577956?language=en
• 关键词: Experimental; test; consequences; host; parasite

Co-evolutionary interactions between host and parasite are predicted to be of prime importance in the evolution of organisms and biological mechanisms. Although they have been intensively studied theoretically, convincing empirical evidence is still scarce. The proposed project provides a comprehensive experimental test of the consequences of host-parasite co-evolution with a focus on seven key predictions. It is based on a co-evolution selection experiment under controlled laboratory conditions followed by extensive phenotypic and molecular analysis. The approach relies on a unique model system, consisting of the nematode Caenorhabditis elegans as a host and its micro-parasite Bacillus thuringiensis, which are both ideally suited to a versatile experimental analysis. The results of this project are expected to have an impact on four biological research themes that are of particular current interest: the animal innate immune system, bacterial virulence, life-history trade-offs, and the maintenance and generation of biological diversity.

预计宿主和寄生虫之间的共同进化相互作用在生物体和生物机制的进化中至关重要。尽管从理论上对它们进行了深入研究，但令人信服的经验证据仍然很少。拟议的项目对宿主-寄生虫共同进化的后果进行了全面的实验测试，重点是七个关键预测。它基于受控实验室条件下的共同进化选择实验，然后进行广泛的表型和分子分析。该方法依赖于一个独特的模型系统，该系统由作为宿主的线虫秀丽隐杆线虫及其微型寄生虫苏云金芽孢杆菌组成，两者都非常适合多功能实验分析。该项目的结果预计将对当前特别感兴趣的四个生物学研究主题产生影响：动物先天免疫系统、细菌毒力、生活史权衡以及生物多样性的维持和产生。