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Role of neuropeptides and neuroamino acids in central regulation of blood pressure

神经肽和神经氨基酸在血压中枢调节中的作用

基本信息

批准号：
59480123
负责人：
FURUKAWA Tatsuo
金额：
$ 4.1万
依托单位：
Fukuoka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1984
资助国家：
日本
起止时间：
1984 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-59480123/
关键词：
Renin Angiotensin Taurine <gamma> -Aminobutyric acid Central Nervous system Blood Pressure 水・食塩摂取

项目摘要

1) In Wistar rats, angiotensin <II> (A <II> ) injected into the posterior hypothalamus and renin administered to the cerebroventricle (CV) induces pressor and positive chronotropic responses. A <II> injected to the preoptic area (POA) stimulate water intake, but not salt intake, and renin injected to the same area both water and salt intakes. 2) Taurine and <gamma> -aminobutyric acid (GABA) i.c.v. do not elicit fluid intakes, but show depressor and negative chronotropic responses. 3) These two amino acids can antagonize central effects of renin and A <II> on cardiovascular system and fluid intakes. However, these acids do not affect pressor responses to centrally administered prostaglandin <F_(2(alpha))> , carbachol and histamine. Among amino acids, cystein, methionine, cystein sulfinic acid and alanine are lack of showing such antagonism. Thus taurine and GABA seem to be selectively antagonize for A <II> and renin. 4) Stimulation of fluid intakes produced by POA injection of A <II> or … More renin is inhibited by GABA and taurine administered to CV as well as POA at 1/10 smaller dose. However pressor responses to POA injected A <II> is inhibited by CV administration of these acids, but not by POA administration. A <II> administered to the suprachiasmatic nucleus bring about moderate rise of blood pressure, but, when administered to paraventricular nucleus and central amygdaloid nucleus, it do not exert act on blood pressure. Thus, POA seems to be one of site of antagonism for fluid intake, but not for blood pressure. 5) In spontaneously hypertensive rats (SHR), pressor responses to A <II> and renin injected to CV or POA are potentiated as compared with those in control Wistar-Kyoto rats. Salt intake, but not water intake, produced by POA injection of A <II> or renin is also exaggerated in SHR. On the contrary, depressor response to taurine administered into CV is reduced in SHR. These central effects of A <II> and renin in SHR and Wistar Kyoto rats are inhibited by central administration of taurine or GABA. 6) When 3% taurine-contained water is given to SHR from 4- to 15 weeks after birth, such exaggerated central effects of A <II> and renin on blood pressure and salt appetite are markedly reduced, in addition to inhibition of development of hypertension. 7) In conclusion, renin and angiotensin seem to be centrally involved in development and maintenance of hypertension and these effects are antagonized taurine and GABA, neuroamino acids. Less

1) Wistar大鼠下丘脑后部注射血管紧张素<II> (A <II>)和脑室肾素（CV）可诱导升压反应和正向变时反应。A <II>注入视前区（POA）刺激水的摄入，但不刺激盐的摄入，肾素注入同一区域既刺激水又刺激盐的摄入。2)牛磺酸和< γ > -氨基丁酸（GABA）不引起液体摄入，但表现出抑制和负性变时反应。3)这两种氨基酸可拮抗肾素和A <II>对心血管系统和液体摄入的中枢作用。然而，这些酸不影响中央给药前列腺素<F_(2(α))>、氨基酚和组胺的降压反应。氨基酸中，半胱氨酸、蛋氨酸、半胱氨酸、亚磺酸和丙氨酸缺乏这种拮抗作用。因此，牛磺酸和GABA似乎对A <II>和肾素具有选择性拮抗作用。1/10剂量的谷丙磺酸和氨基丁酸能抑制更多的肾素。然而，注射A <II>的POA的加压反应被这些酸的CV给药抑制，而POA给药不被抑制。给药于视交叉上核可使血压中度升高，但给药于室旁核和中央杏仁核对血压无作用。因此，POA似乎是液体摄入的拮抗部位之一，而不是血压的拮抗部位。5)在自发性高血压大鼠（SHR）中，与Wistar-Kyoto对照大鼠相比，A <II>和肾素注射对CV或POA的升压反应增强。在SHR中，注射A <II>或肾素的POA产生的盐摄入量，而不是水摄入量也被夸大。相反，在SHR中，牛磺酸对CV的抑制反应降低。在SHR和Wistar Kyoto大鼠中，A <II>和肾素的这些中枢作用被牛磺酸或GABA的中枢作用所抑制。6)出生后4 ~ 15周给予SHR 3%牛磺酸水，除了抑制高血压的发展外，A <II>和肾素对血压和盐食欲的夸大中枢作用显著降低。7)总之，肾素和血管紧张素似乎在高血压的发生和维持中起主要作用，这些作用是由牛磺酸和GABA等神经氨基酸拮抗的。少