Involvement of neuropeptides and amino acids in central regulation of blood pressure.
神经肽和氨基酸参与血压的中枢调节。
基本信息
- 批准号:63480121
- 负责人:
- 金额:$ 3.2万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (B)
- 财政年份:1988
- 资助国家:日本
- 起止时间:1988 至 1990
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The experiments were undertaken in un-anesthetized and freely moving rats. 1)Renin and angiotensin II(AII)administered into the cerebroventricle caused pressor responses via stimulating AII receptors, which was potentiated in spontaneously hypertensive rats(SHR)than those in control Wistar Kyoto rats(WKY). 2)AII receptors involved in central pressor responses are found in the preoptic area(POA)and suprachiasmatic nucleus, but not in the central amygdaloid nucleus and paraventricular nucleus. The pressor responses are potentiated in SHR at only POA, and this hyperresponsiveness seems to be involved in not evocation but maintenance of hypertension, on the basis of differences between 6 and 15 weeks SHR. Pressor responses to AII are antagonized by central administration of GABA or taurine. The antagonism is not mediated by directly acting on POA, but by indirectly acting on other brain sites. 3)AII induced not only pressor responses but also an increase of water and salt intake, which are also potentiated in SHR. For this potentiation in fluid intakes, POA is also importantly involved. These responses to AII are antagonized by atrial natriuretic peptide(ANP)at POA and posterior hypothalamus(PH)in SHR but not in WKY, indicating responsiveness to ANP is also potentiated in SHR at those areas. The results suggest that the activities of brain AII and ANP neuronal system may play an important role in central controlling the cardiovascular system at POA and PH and is altered at these areas in genetically hypertensive rats.
实验在未麻醉和自由活动的大鼠中进行。1)将肾素和血管紧张素II(AII)注射入左心室,通过刺激AII受体引起升压反应,自发性高血压大鼠(SHR)的升压反应比对照Wistar京都大鼠(WKY)的升压反应增强。2)在视前区(POA)和视交叉上核中发现了参与中枢升压反应的AII受体,但在中央杏仁核和室旁核中没有发现。仅在POA时,SHR的升压反应增强,根据6和15周龄SHR之间的差异,这种高反应性似乎与高血压的维持而不是诱发有关。对AII的升压反应被GABA或牛磺酸的中枢给药拮抗。这种拮抗作用不是通过直接作用于POA,而是通过间接作用于其他脑部位来介导的。3)AII不仅引起升压反应,而且还增加了水和盐的摄入量,这在SHR中也是增强的。对于液体摄入量的增强,POA也发挥了重要作用。在SHR的POA和后下丘脑(PH),心房钠尿肽(ANP)拮抗AII的这些反应,但在WKY中不拮抗,表明在SHR的这些区域对ANP的反应性也增强。结果提示,遗传性高血压大鼠在POA和PH时脑AII和ANP神经元系统的活动可能在心血管系统的中枢控制中起重要作用,并在这些区域发生改变。
项目成果
期刊论文数量(34)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
崎村 正良: "高血圧自然発症ラットにおけるreninーangiotensin系およびatrial natriuretic peptideの中枢性循環調節における作用相関" 福岡大学医学紀要. 16. 79-96 (1989)
Masayoshi Sakimura:“肾素-血管紧张素系统和心钠素对自发性高血压大鼠中枢循环调节的影响的相关性”福冈大学医学通报16. 79-96 (1989)。
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- 影响因子:0
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松田年浩: "視索前野におけるangiotensin IIによる昇圧反応と、taurine,γーaminobutyric acid" 福岡大学医学紀要. 15. 63-75 (1988)
Toshihiro Matsuda:“血管紧张素 II 诱导的视前皮质和牛磺酸、γ-氨基丁酸的升压反应”福冈大学医学通报 15. 63-75 (1988)。
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Sakimura, M.: "Interaction between renin-angiotensin II and atrial natriuretic peptide in contral effects on blood pressure and fluid intakes in spontaneously hypertensive rats (in Japanese)." Med. Bull. Fukuoka Univ.16. 79-96 (1989)
Sakimura, M.:“肾素-血管紧张素 II 和心房钠尿肽之间的相互作用对自发性高血压大鼠的血压和液体摄入量的控制作用(日语)。”
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Shibata,K.et al.: "Antagonism of central pressor response to angiotensin II by α-human atrial natriuretic polypeptide at the preoptic area and posterior hypothalamus in rats." Neuropharmacology. (1992)
Shibata, K. 等人:“α-人心房钠尿多肽在大鼠视前区和下丘脑后部对血管紧张素 II 的中枢升压反应的拮抗作用 (1992)。
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Shibata, K., Kskimura, M. and Furukawa, T.: "Antagonism of central pressor response to angiotensin II by alpha-human atrial natriuretic polypeptide at the preoptic and posterior hypothalamus in rats." Neuropharmacology.
Shibata, K.、Kskimura, M. 和 Furukawa, T.:“α-人心房钠尿肽在大鼠视前和下丘脑后部对血管紧张素 II 的中枢升压反应的拮抗作用。”
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FURUKAWA Tatsuo其他文献
FURUKAWA Tatsuo的其他文献
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Analysis of the novel gene identified using a SEREX method in the senrm of bone marrow failure patients
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18591048 - 财政年份:2006
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$ 3.2万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identification of novel leukemia associated antigen which may useful for immunotherapy of leukemia patients
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- 批准号:
15590997 - 财政年份:2003
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$ 3.2万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The effects of hematopoietic cytokines, and the changes of transcriptional factors during the proliferation, differentiation, and maturation of basophilic and eosinophilic progenitors
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- 批准号:
09671102 - 财政年份:1997
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$ 3.2万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Role of neuropeptides and neuroamino acids in central regulation of blood pressure
神经肽和神经氨基酸在血压中枢调节中的作用
- 批准号:
59480123 - 财政年份:1984
- 资助金额:
$ 3.2万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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