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Role of lower gastrointestinal tract for voluntary food intake in ruminants

下胃肠道对反刍动物自愿食物摄入的作用

基本信息

批准号：
60480076
负责人：
TSUDA Tsuneyuki
金额：
$ 4.1万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480076/
关键词：
ruminant contlol of feed intake lower digestive tract 酢酸

项目摘要

Recently it is reported that glucose, fatty acid or amino acid in the digesta entered into the lower gastro-intestinal tracts affect on the gastric movement and on voluntary feed intake in monogastric animals. In ruminants, however, few investigations were reported on this aspects because the attentions were particularly focused in the role of the rumen functions. The present investigation planned to examine the participation of lower digestive tract on the voluntary feed intake in sheep.Method: Duodenal cannula fitted sheep were used for sampling of the abomasal digesta and for introducing of several substance into the lower gut. Rumen contraction and electromyographic discharge from abomasum were measured as well as the amount of feed intake in these sheep.Results: The animal stopped eating when the rate of flow of digesta from abomasum reached the maximum in normal feeding conditions. Introductions of volatile fatty acids into duodenum inhibited the amount of feed intake but those of glucose, lactic acid and casein hydrolysate did not show any effect on the feed intake. The injection of same amount of VFA into mesenteric vein did exert no influences on the feed intake. The solutions of acetate with different concentrations were introduced into the duodenum to know the threshold concentration of acetate for inhibition of the feed intake. It was found that the introduction of acetate with the concentrations of above 60mM reduced both digesta outflow from the abomasum and amount of feed intake. In addition, the rumen movement and abomasal electromyographical discharge were also lowered by this treatment. However, addition of tetracain, a local anesthetic, to the acetate solution clearly moderated the inhibitory effects of acetic acid. Above results suggest that the acetate receptors located in the lumen side of lower gut may project the impulses to the feeding center to control the amount of feed intake in sheep.

最近有报道称，进入下胃肠道的食糜中的葡萄糖、脂肪酸或氨基酸会影响单胃动物的胃运动和自主摄食量。然而，在反刍动物中，这方面的研究报道很少，因为人们的注意力特别集中在瘤胃功能的作用。本研究旨在探讨下消化道对绵羊采食量的影响。方法：采用十二指肠插管法，对绵羊皱胃进行取样，并将几种物质导入下消化道。结果：在正常饲养条件下，当皱胃分泌物流量达到最大值时，绵羊停止进食。十二指肠中添加挥发性脂肪酸可抑制采食量，而葡萄糖、乳酸和酪蛋白水解物对采食量无影响。肠系膜静脉注射等量VFA对采食量无影响。将不同浓度的乙酸盐溶液注入十二指肠，以确定乙酸盐抑制采食量的阈值浓度。结果发现，引入浓度高于60 mM的乙酸盐减少了皱胃中的瘤胃流出量和采食量。此外，瘤胃运动和真胃肌电放电也被降低。然而，添加丁卡因，局部麻醉剂，醋酸溶液明显缓和醋酸的抑制作用。以上结果提示，位于下消化道腔侧的醋酸受体可能通过向摄食中枢投射冲动来控制绵羊的采食量。