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Experimental and clinical study of NMR in pulmonary medicine.

核磁共振在肺医学中的实验和临床研究。

基本信息

批准号：
60480218
负责人：
YAMABAYASHI Hajime
金额：
$ 4.03万
依托单位：
Tokai University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

项目摘要

1. Animal experiments(1) Tissue discrimination by relaxation times : We measured T1 and T2 or rat lung tissues in vitro. The values showed characteristic change in the follwing experimental lung lesions ; cardiogenic pulmonary edema, non-cardiogenic pulmonary edema, active radiation pneumonitis, radiation fibrosis and pneumonia. The T2 of all lung tissue showed multiexponential transverse magnetization decay consisting of two distinct T2 values of fast and slow. We speculate that these two components reflect the biological state of intra and the extracellular water of lung tissue.(2) <^(23)Na> spectrum of lung tissues : Separation of the intracellular and the extracellular Na of lung tissue was possible by the chemical shift of <^(23)Na> induced by infusing the Na shift agent into the pulmonary artery. This method enables the observation of dynamics of water and sodium in lung injury.2. Application of MRI for lung diseases(1) We measured T1 and T2 of pathological human lung tissues in vitro and estimated the signal intensity of each lesions in MRI : Viable lung cancer and necrotic tumor can be discriminated by the T1 and the T2 in vitro. The value of T1 and T2 in inflammatory lung tissue were dependent on its histological stage of acute or chronic (fibrotic). Fibrotic lung showed significantry short values of T1 and T2 compared to viable lung cancer and acute inflammtory lung. There were not significant differences of relaxation times between viable lung cancer and inflammatory lung in acute stage. (2) Clinical application of MRI in lung cancer patients : The T2 weighted image with long TR and TE was preferable for qualitative diagnsis of pathological lung. Discrimination of necrosis and fibrotic lung from viable tumor was possible by MRI. The results suggested that this method is of value of clinical practice for the non-invasive evaluation of therapeutic effects of lung cancer.

1.动物实验（1）通过弛豫时间进行组织区分：我们在体外测量了T1和T2或大鼠肺组织。这些值显示了以下实验性肺部病变的特征性变化；心源性肺水肿、非心源性肺水肿、活动性放射性肺炎、放射性纤维化和肺炎。所有肺组织的 T2 显示出多指数横向磁化强度衰减，由快和慢两个不同的 T2 值组成。我们推测这两个成分反映了肺组织内部和细胞外水的生物状态。(2)肺组织的<^(23)Na>光谱：通过将Na位移剂注入肺动脉引起<^(23)Na>的化学位移，可以分离肺组织的细胞内和细胞外Na。该方法可以观察肺损伤中水和钠的动态变化。 2． MRI在肺部疾病中的应用(1)体外测量人体病理肺组织的T1和T2，并估计MRI中各病灶的信号强度：通过体外T1和T2可区分活肺癌和坏死肿瘤。炎症肺组织中T1和T2的值取决于其急性或慢性（纤维化）的组织学阶段。与活肺癌和急性炎症肺相比，纤维化肺的 T1 和 T2 值显着缩短。急性期存活肺癌与炎性肺的弛豫时间无显着差异。 (2)MRI在肺癌患者中的临床应用：长TR和TE的T2加权图像更适合病理肺的定性诊断。通过 MRI 可以将坏死和纤维化肺与活肿瘤区分开来。结果表明该方法对于肺癌疗效的无创评价具有临床应用价值。