Neuropsychological research on frontal lobe function in schizophrenia: A relationship between visual cognitive context and eye movements.

精神分裂症额叶功能的神经心理学研究：视觉认知背景与眼球运动之间的关系。

• 批准号: 60480260
• 负责人: OKAZAKI Yuji
• 金额: $ 2.82万
• 依托单位: University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480260/
• 关键词: Schizophrenia; Frontal lobe function; Cognitive Context; Strategy; Eye Movements; Ambiguous figure

The purpose of this study is to investigate the frontal lobe function being reflected as a strategy or a process of 'context-updating' which is performed by schizophrenics, recording eye movements during the visual cognitive tasks. In the first step, we prepared a paradigm in which eye movements can be led to tracing strategies employed in processing visual stimuli, and devised the recording and analyzing system for the data of eye movements using the appratus (NAC, model V) and micro-computer (NEC, PC9801, VM2). Specifically, in order to explore the trends of visual information processing, we newly developed the computerized method by which on a screen we can examine the data of eye movements accumulated trial by trial, or subject by subject within a given stimulus pattern. In the second step, we conducted two kinds of experiments in which eye movements were recorded during tasks. Sixteen schizophrenic outpatients (mean age 39. 1 years) and 7 normal volunteers served as subjects. All … More schizophtrenics met the diagnostic criteria of DSM-III for schizophrenic disorders. In experiment I, the two kinds of ambiguous figures, i.e., "Duck and Rabbit" drawn by Jastrow and "Young Woman and Old Women" drawn by Boring, were employed as a stimuli. In one condition of this experiment I, subjects were required to perceive only the one aspect of each of ambiguous figures. In another condition, they were instructed to make an alternation between two different images evoked by a given figure, as correctly and quickly as possible. In experiment II, we employd the Neisser's visual search task and modified for this experiment. Prior to these experiments, Benton Visual Retention Test were administered for all subjects. As a result, we found that schizophrenic patients were mainly divided into the poor-performed group and the well-perrformed group. Especially, several of the schizophrenic subjects included in the latter group performed the tasks as well as normal subjects. These results claimed that neither the frontal lobe dysfunction nor the cognitive dysfunction in schizophrenics should be assesed collectively. Less

本研究的目的是研究精神分裂症患者在视觉认知任务中记录眼球运动时，额叶功能被反映为一种策略或一种“背景更新”过程。在第一步中，我们准备了一种可以将眼动引导到视觉刺激处理中的跟踪策略的范式，并使用设备(NAC，Model V)和微型计算机(NEC，PC9801，VM2)设计了眼动数据的记录和分析系统。具体地说，为了探索视觉信息处理的趋势，我们新开发了一种计算机化的方法，通过这种方法，我们可以在屏幕上检查试验积累的眼动数据，或者在给定的刺激模式下逐个对象地检查眼动数据。在第二步中，我们进行了两种实验，记录任务过程中的眼动。16例精神分裂症门诊患者(平均年龄39岁。1岁)和7名正常志愿者作为研究对象。所有…更多的精神分裂症患者符合DSM-III对精神分裂症的诊断标准。实验一采用Jastrow绘制的《鸭子与兔子》和无聊绘制的《青年妇女与老年妇女》两种模棱两可的人物作为刺激。在实验一的一个条件下，受试者被要求只感知每个模棱两可的数字的一个方面。在另一种情况下，受试者被要求以尽可能准确和快速的速度，在给定图形所唤起的两个不同图像之间进行交替。在实验二中，我们采用了Neisser的视觉搜索任务，并针对本实验进行了改进。在这些实验之前，对所有受试者进行了本顿视觉保持测验。结果发现，精神分裂症患者主要分为表现不佳组和表现良好组。特别是后一组中的几个精神分裂症受试者的任务完成得和正常受试者一样好。这些结果表明，精神分裂症患者的额叶功能障碍和认知功能障碍都不应被集体评估。较少

项目成果

Osamu Saitoh: "Eye movements as a representation of the strategy in visual cognition. (a submitted paper for the presentation)" The 9th Annual Meeting of Japanese Society of Biological Psychiatry. Sapporo, 1987.

Osamu Saitoh：“眼睛运动作为视觉认知策略的代表。（提交的演讲论文）”日本生物精神病学学会第九届年会。

O.Saitoh: The 4th European Conference on Eye Movements(E.C.E.M.4)(1987).

O.Saitoh：第四届欧洲眼动会议（E.C.E.M.4）（1987）。

斎藤治: 第9回日本生物学的精神医学会(1987).

Osamu Saito：第九届日本生物精神病学学会（1987 年）。

Hiroshi Aikawa: "Wisconsin Card Sorting Test using micro-computer." The 10th congress of Neuropsychology Association of Japan Himeji, 1986.

Hiroshi Aikawa：“使用微型计算机的威斯康星州卡片分类测试。”

斎藤治: 神経研究の進歩. 30. 827-840 (1986)

Osamu Saito：神经研究进展 30. 827-840 (1986)。