Multi-axial Physical Brain Examination on Schizophrenia.

对经DSM-III诊断的精神分裂症患者和正常志愿者进行三维体检研究，以西门子Somtom CR扫描仪采集的CT数据为第一维度，在数字化条件下进行。在两组比较中，精神分裂症患者的平均CT密度(N=47，34.3&lt；+-lt；2.67)显著低于对照组(N=13，35.64&lt；+-gt；1)。以1231-IMP SPECT结合动脉采血法测定rCBF时，平均全脑CBF(N=21，62.7&lt；正-负19.3ml/100g/m in较对照组(N=30，56.5；+-gt；17.6m l/100g/m)下降。由于脑血流量受年龄的影响较大，经回归分析，最适宜的回归方程为：脑血流量指数=对数(Cbf)=4.59-0.0129×ag.正常对照组平均校正的脑血流指数为4.21m l；0.22(N=21)，呈正态分布(Wilk-Shapiro‘s检验)。精神分裂症组为3.98+-0.38(N=第三维度)，用16ch定位进行脑电功率检测(FFT分析)。在EEG研究中，精神分裂症患者的显著变化是慢频段功率增加(+1~+21%)，α活动减弱，β带活动显著增加(P&lt；0.05)。通过这些三维定量研究，既没有观察到区域性(包括额叶功能障碍)，也没有观察到侧向性。因此，我们未能再次证实这些假设，但使用这些三维曲线图，我们可能能够客观地区分精神分裂症病例和正常人群。

Three dimensional physical examination study was carried out on schizophrenics diagnosed by DSM-III and normal volunteers as the control.As the first dimension, CT data were sampled from SIEMENS SOMATOM CR scanner on the condition of digital data. Some fresh schizophrenics have showed diffuse low dencity CT-value, however, this finding was transitional and it's CT-value has showed recovered to the normal range.In the comparison between two group, mean CT density of the schizophrenics (N=47, 34.3<plus-minus>2.67) were significantly (p<0.05) lower than that of the control (N=13, 35.64<plus-minus>1As the second dimension, in the rCBF measurement using 1231-IMP SPECT with arterial blood sampling method, mean schizophrenic whole brain CBF (N=21, 62.7<plus-minus>19.3ml/100g/min) showed decreased from that of the control (N=30, 56.5<plus-minus>17.6ml/100g/mTherefore CBF is largely influenced by the aging, regression analysis was carried out, then the most suitable regression function (R-square=0.4997) was as follows ;CBF index = log (CBF) = 4.59-0.0129Xage.Mean corrected CBF index in the normal control was 4.21<plus-minus>0.22 (N=21), and it's distribution showed normal distribution (Wilk-Shapiro's test). On the other hand, that of the schizophrenics group was 3.98<plus-minus>0.38 (N=As the third dimension, EEG power examination (FFT analysis) was carried out by 16ch location. In the EEG study, remarkable changes in the schizophrenic patients were increase in the slow frequency band power (+1 to+21%up), fade down alpha activity, and significantly (P<0.05) increase of beta band activity.Throughout these three dimensional quantitative studies, neither regionality (including frontal lobe dysfunction) nor laterality was observed. Thus, we failed to reconfirm these hypotheses.However using these three dimensional plots, we might be able to discriminate schizophrenic cases from the normal objectively.