Multi-axial Physical Brain Examination on Schizophrenia.

精神分裂症的多轴物理脑检查。

• 批准号: 63480259
• 负责人: OKAZAKI Yuji
• 金额: $ 3.26万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63480259/
• 关键词: Schizophrenia; CT-scan; 123I-IMP SPECT; EEG topography; 脳波等電位図; 精神分裂病; 局所脳血流量; ^<123>TーIMP; SPECT; 多元的大脳生理機能評価

Three dimensional physical examination study was carried out on schizophrenics diagnosed by DSM-III and normal volunteers as the control.As the first dimension, CT data were sampled from SIEMENS SOMATOM CR scanner on the condition of digital data. Some fresh schizophrenics have showed diffuse low dencity CT-value, however, this finding was transitional and it's CT-value has showed recovered to the normal range.In the comparison between two group, mean CT density of the schizophrenics (N=47, 34.3<plus-minus>2.67) were significantly (p<0.05) lower than that of the control (N=13, 35.64<plus-minus>1As the second dimension, in the rCBF measurement using 1231-IMP SPECT with arterial blood sampling method, mean schizophrenic whole brain CBF (N=21, 62.7<plus-minus>19.3ml/100g/min) showed decreased from that of the control (N=30, 56.5<plus-minus>17.6ml/100g/mTherefore CBF is largely influenced by the aging, regression analysis was carried out, then the most suitable regression function (R-square=0.4997) was as follows ;CBF index = log (CBF) = 4.59-0.0129Xage.Mean corrected CBF index in the normal control was 4.21<plus-minus>0.22 (N=21), and it's distribution showed normal distribution (Wilk-Shapiro's test). On the other hand, that of the schizophrenics group was 3.98<plus-minus>0.38 (N=As the third dimension, EEG power examination (FFT analysis) was carried out by 16ch location. In the EEG study, remarkable changes in the schizophrenic patients were increase in the slow frequency band power (+1 to+21%up), fade down alpha activity, and significantly (P<0.05) increase of beta band activity.Throughout these three dimensional quantitative studies, neither regionality (including frontal lobe dysfunction) nor laterality was observed. Thus, we failed to reconfirm these hypotheses.However using these three dimensional plots, we might be able to discriminate schizophrenic cases from the normal objectively.

对符合DSM-III诊断标准的精神分裂症患者和正常志愿者进行三维体检研究，第一维度采用西门子SOMATOM CR扫描仪在数字数据条件下采集的CT数据。精神分裂症组与对照组比较，精神分裂症组平均CT密度（N=47，34.3 <plus-minus>± 2.67）显著低于对照组（N=13，35.64）（P&lt;0.05）<plus-minus>。62.7 <plus-minus>± 19.3ml/100 g/min）较对照组（N=30，56.5 <plus-minus>± 17.6ml/100 g/min）明显降低，说明年龄对脑血流量有很大影响，对脑血流量进行回归分析，得到最佳回归方程为：脑血流量指数= log（CBF）= 4.59- 0.0129Xage，校正后的正常对照组平均脑血流量指数为4.21 <plus-minus>± 0.22（N=21），其分布呈正态分布（Wilk-Shapiro检验）。精神分裂症组为3.98 ± <plus-minus>0.38（N= 0.001）。作为第三维度，采用16通道定位进行脑电功率检测（FFT分析）。EEG的三维定量研究中，精神分裂症患者的显著变化是慢频带功率增加（+1 ~+21%），α活动减弱，β活动显著增加（P&lt;0.05），但未见区域性（包括额叶功能障碍）和偏侧性。因此，我们未能再次证实这些假设，但利用这些三维图，我们可能能够客观地区分精神分裂症患者和正常人。

项目成果

中村 千秋ら: "頭部X線CT像における脳領域の抽出方法" 電子通信情報学会. 1E90ー95. 91-98 (1990)

Chiaki Nakamura 等人：“头部 X 射线 CT 图像中的脑区域提取方法”，电子、通信和信息工程师研究所 1E90-95 (1990)。

中村 千秋ら: "頭部X線CT像における脳領域の抽出方法" 電子通信報学会. IE90ー95. 91-98 (1990)

Chiaki Nakamura 等人：“头部 X 射线 CT 图像中脑区域的提取方法”，电子和通信工程师协会 IE90-95 (1990)。

Chiaki Nakamura, Chen Xin, Akira nakamura, Jun Uchino: "Cerebral detection method on the brain CT image." Journal of Electronic information and communication. 1E90-95. 91-98 (1990)

Chiaki Nakamura、Chen Xin、Akira nakamura、Jun Uchino：“脑 CT 图像上的脑部检测方法”。

内野 淳ら: "X線CTによる精神分裂病者の画像診断" 臨床精神医学. 19. 1827-1838 (1990)

Jun Uchino 等人：“使用 X 射线 CT 进行精神分裂症的图像诊断”《临床精神病学》19. 1827-1838 (1990)。

Jun Uchino: "Schizophrenia and CT scan imaging." Journal of Clinical Psychiatry. Vol 19. 1827-1838 (1990)

Jun Uchino：“精神分裂症和 CT 扫描成像。”