Multi-axial Physical Brain Examination on Schizophrenia.

对DSM-III诊断的精神分裂症患者和正常志愿者进行三维体格检查研究。作为第一个维度，CT数据在数字数据的条件下从SIEMENS SOMATOM CR扫描仪上采样。部分新发精神分裂症患者ct表现为弥漫性低密度，但这是过渡性的，其ct值已恢复到正常范围。两组比较，精神分裂症患者的平均CT密度（N=47, 34.3<正负>.67）显著低于对照组（N=13, 35.64<正负>）（p<0.05）。作为第二次元，采用1231-IMP SPECT动脉采血法测量rCBF时，精神分裂症患者全脑平均CBF （N=21, 62.7<正负>9.3 ml/100g/min）低于对照组（N=30, 56.5<正负>7.6 ml/100g/min），因此，CBF在很大程度上受年龄的影响。进行回归分析，得到最合适的回归函数（r方=0.4997）为：CBF指数= log (CBF) = 4.59-0.0129Xage。正常对照组校正后的平均脑血流指数为4.21<正负>0.22 (N=21)，其分布符合正态分布（Wilk-Shapiro检验）。精神分裂症组为3.98<正负>0.38 （N=）作为第三维度，采用16ch定位进行脑电功率检查（FFT分析）。在脑电图研究中，精神分裂症患者慢频段功率增加（+1 ~ +21%），α频段活动减弱，β频段活动显著增加（P<0.05）。在这些三维定量研究中，既没有观察到区域性（包括额叶功能障碍），也没有观察到侧性。因此，我们未能再次确认这些假设。然而，利用这些三维图，我们可能能够客观地区分精神分裂症病例和正常人。

Three dimensional physical examination study was carried out on schizophrenics diagnosed by DSM-III and normal volunteers as the control.As the first dimension, CT data were sampled from SIEMENS SOMATOM CR scanner on the condition of digital data. Some fresh schizophrenics have showed diffuse low dencity CT-value, however, this finding was transitional and it's CT-value has showed recovered to the normal range.In the comparison between two group, mean CT density of the schizophrenics (N=47, 34.3<plus-minus>2.67) were significantly (p<0.05) lower than that of the control (N=13, 35.64<plus-minus>1As the second dimension, in the rCBF measurement using 1231-IMP SPECT with arterial blood sampling method, mean schizophrenic whole brain CBF (N=21, 62.7<plus-minus>19.3ml/100g/min) showed decreased from that of the control (N=30, 56.5<plus-minus>17.6ml/100g/mTherefore CBF is largely influenced by the aging, regression analysis was carried out, then the most suitable regression function (R-square=0.4997) was as follows ;CBF index = log (CBF) = 4.59-0.0129Xage.Mean corrected CBF index in the normal control was 4.21<plus-minus>0.22 (N=21), and it's distribution showed normal distribution (Wilk-Shapiro's test). On the other hand, that of the schizophrenics group was 3.98<plus-minus>0.38 (N=As the third dimension, EEG power examination (FFT analysis) was carried out by 16ch location. In the EEG study, remarkable changes in the schizophrenic patients were increase in the slow frequency band power (+1 to+21%up), fade down alpha activity, and significantly (P<0.05) increase of beta band activity.Throughout these three dimensional quantitative studies, neither regionality (including frontal lobe dysfunction) nor laterality was observed. Thus, we failed to reconfirm these hypotheses.However using these three dimensional plots, we might be able to discriminate schizophrenic cases from the normal objectively.