Multi-axial Physical Brain Examination on Schizophrenia.

对符合DSM-Ⅲ诊断标准的精神分裂症患者和正常志愿者进行三维体格检查研究，第一维为SIEMENS SOMATOM CR扫描仪数字化采集的CT数据。精神分裂症组与对照组比较，精神分裂症组平均CT密度（N=47，34.3 <plus-minus>± 2.67）显著低于对照组（N=13，35.64）（P&lt;0.05）<plus-minus>。62.7 <plus-minus>± 19.3ml/100 g/min）较对照组（N=30，56.5 <plus-minus>± 17.6ml/100 g/min）明显降低，说明年龄对脑血流量有很大影响，对脑血流量进行回归分析，得到最佳回归方程为：脑血流量指数= log（CBF）= 4.59- 0.0129Xage，校正后的正常对照组平均脑血流量指数为4.21 <plus-minus>± 0.22（N=21），其分布呈正态分布（Wilk-Shapiro检验）。精神分裂症组为3.98 ± <plus-minus>0.38（N= 0.001）。作为第三维度，采用16通道定位进行脑电功率检测（FFT分析）。EEG的三维定量研究中，精神分裂症患者的显著变化是慢频带功率增加（+1 ~+21%），α活动减弱，β活动显著增加（P&lt;0.05），但未见区域性（包括额叶功能障碍）和偏侧性。因此，我们未能再次证实这些假设，但利用这些三维图，我们可能能够客观地区分精神分裂症患者和正常人。

Three dimensional physical examination study was carried out on schizophrenics diagnosed by DSM-III and normal volunteers as the control.As the first dimension, CT data were sampled from SIEMENS SOMATOM CR scanner on the condition of digital data. Some fresh schizophrenics have showed diffuse low dencity CT-value, however, this finding was transitional and it's CT-value has showed recovered to the normal range.In the comparison between two group, mean CT density of the schizophrenics (N=47, 34.3<plus-minus>2.67) were significantly (p<0.05) lower than that of the control (N=13, 35.64<plus-minus>1As the second dimension, in the rCBF measurement using 1231-IMP SPECT with arterial blood sampling method, mean schizophrenic whole brain CBF (N=21, 62.7<plus-minus>19.3ml/100g/min) showed decreased from that of the control (N=30, 56.5<plus-minus>17.6ml/100g/mTherefore CBF is largely influenced by the aging, regression analysis was carried out, then the most suitable regression function (R-square=0.4997) was as follows ;CBF index = log (CBF) = 4.59-0.0129Xage.Mean corrected CBF index in the normal control was 4.21<plus-minus>0.22 (N=21), and it's distribution showed normal distribution (Wilk-Shapiro's test). On the other hand, that of the schizophrenics group was 3.98<plus-minus>0.38 (N=As the third dimension, EEG power examination (FFT analysis) was carried out by 16ch location. In the EEG study, remarkable changes in the schizophrenic patients were increase in the slow frequency band power (+1 to+21%up), fade down alpha activity, and significantly (P<0.05) increase of beta band activity.Throughout these three dimensional quantitative studies, neither regionality (including frontal lobe dysfunction) nor laterality was observed. Thus, we failed to reconfirm these hypotheses.However using these three dimensional plots, we might be able to discriminate schizophrenic cases from the normal objectively.