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Objective Measurement and Biological Basis of Anxiety Assessed by Frontal Midline Theta Activity (Fm<theta>)

通过额叶中线 Theta 活动 (Fm<theta>) 评估焦虑的客观测量和生物学基础

基本信息

批准号：
60480262
负责人：
MIZUKI Yasushi
金额：
$ 1.41万
依托单位：
Yamaguchi University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1987
项目状态：
已结题

项目摘要

The distinct theta rhythm in the frontal midline area during performance of mental tasks has been called Fm<theta>. It is well known that the relief from anxiety might be involved in the appearance of Fm<theta>. In the present study, the objective measurement and the biological basis of anxiety were investigated by using Fm<theta> as an index.The plasma catecholamine responses to mental stress were studied using male students with (n=12) and without (n=12) Fm<theta>. The contents of plasma catecholamines, the appearance time of Fm<theta> and the anxiety scores of two groups were examined during the rest, and before, during and after the calculation. The concentrations of catecholamines in the Fm<theta> appearance group showed lower levels at all times compared to those in the non appearance group. The relief from anxiety in the non appearance group was characterized by a decrease of NA turnover while a decrease of anxiety in the Fm<theta> appearance group involved an increase of DA tur … More nover.The subjects in the Fm<theta> appearance group (n=9) and in the non appearance group (n=9) were given bromocriptine 2.5 mg, sulpiride 50 mg and placebo in a double-blind, crossover design. The appearance of Fm<theta>, the scores of anxiety and the plasma catecholamines were measured before and 1 hr after the drug administration. The similar experiment using clonidine 0.15 mg, yohimbine 5 mg and placebo was also performed. Both an increase of Fm<theta> and a decrease of anxiety in the Fm<theta> appearance group were shown by the stimulation of DA activity, while those in the non appearance group were indicated by the inhibition od DA or NA activity.Twenty eight neurotics and 35 schizophrenics were examined the appearance of Fm<Theta> and the clinical evaluation of symptoms once weekly until Fm<theta> appeared in 2 consecutive weeks, and the plasma catecholamines were also measured before and after the study. A large number of neurotics showed the appearance of Fm<theta> and the inhibition of NA activity according to the improvement of their symptoms. Schizophrenics were divided into two groups, i.e., the Fm<theta> appearance group and the non appearance group. The patients with Fm<theta> responded to the neuroleptics treatment and indicated a decrease of positive symptoms. Less

在执行心理任务期间，额叶中线区域的独特θ节律被称为Fm<theta>。众所周知，焦虑的缓解可能与Fm的出现有关<theta>。本研究以Fm为指标，探讨了焦虑的客观测量方法和生物学基础<theta>，并以12名有和无Fm的男大学生为研究对象，研究了血浆儿茶酚胺对心理应激的反应<theta>。分别<theta>于安静时、计算前、计算中、计算后检测两组患者血浆儿茶酚胺含量、Fm出现时间及焦虑评分。与<theta>未出现组相比，Fm出现组的儿茶酚胺浓度在所有时间均显示出较低的水平。不出现组的焦虑缓解表现为NA周转减少，而出现Fm组的焦虑缓解<theta>涉及DA周转增加。 ...更多信息 Fm<theta>出现组（n=9）和未出现组（n=9）采用双盲交叉设计，分别给予溴隐亭2.5mg、舒必利50mg和安慰剂。分别<theta>于给药前及给药后1 h测定Fm的出现率、焦虑评分及血浆儿茶酚胺水平。用可乐定0.15mg、育亨宾5mg和安慰剂进行类似实验。对<theta><theta>28例神经症患者和35例精神分裂症患者进行了每周一次的Fm<Theta>出现检查和临床症状评定，直至<theta>连续2周出现Fm为止，并在研究前后测定了血浆儿茶酚胺。大量神经症患者根据症状的改善表现出Fm的出现<theta>和NA活性的抑制。精神分裂症患者被分为两组，即，Fm<theta>出现组和非出现组。抗<theta>精神病药物治疗后，Fm患者的阳性症状明显减少。少