Assessment of the myocardial protection in critical neonates

危重新生儿心肌保护作用的评估

• 批准号: 60480317
• 负责人: MATSUDA Hikaru
• 金额: $ 4.29万
• 依托单位: Osaka University Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480317/
• 关键词: neonat and infant; myocardial protection; crystalloid cardioplegia; mitochondrial score; ミトコンドリアスコア; 細胞内浮種スコア; PG12 analogue; single dose法; multiple dose法

1. Results of Experimental Studies in 1985Assessment of the myocardial protectection in infant dogs (n=5) was perfomed under the cardiopulmonary bypass (CPB). 3 of 5 dogs were able to wean off CPB. Mitochondrial score (MtS) and edema score (EdS) of the 3 dogs became worse after reperfusion but there were no difference among them.2.Results of Experimental Studies in 1986Comparison of the single-dose (S) administration of cardioplegia (CP) and multiple-dose (M) CP in the isolated new born rabbit hearts were perfomed. The myocardial protection of S was more effective than that of M in terms of % recovery heart rate (%HR), % water content, MtS and EdS.Comparison of three kinds of crystalloid CP (GIK(S1),GIK with Ca++ and Mg++ (S2) and GIK with Ca++, Mg++ and PGI2 analogue (S3)) were performed in the isolated new born rabbit hearts. The myocardial protection with S3 was more effective than that with S1 and S2 in terms of %HR, % recovery coronary flow, MtS and EdS.

1. 1985年实验研究结果在体外循环（CPB）下对幼犬（n=5）进行心肌保护评估。 5 只狗中有 3 只能够断掉体外循环。 3只犬再灌注后线粒体评分(MtS)和水肿评分(EdS)均有所恶化，但无差异。2.1986年实验研究结果对离体新生兔心脏进行单剂量(S)停跳液(CP)和多剂量(M) CP的比较。在％恢复心率(%HR)、％含水量、MtS和EdS方面，S的心肌保护作用比M更有效。在离体新生兔心脏中对三种晶体CP(GIK(S1)、GIK含Ca++和Mg++(S2)和GIK含Ca++、Mg++和PGI2类似物(S3))进行比较。在％HR、％恢复冠脉流量、MtS和EdS方面，S3的心肌保护比S1和S2更有效。

项目成果

Yoshiki Sawa: "Clinical assessment of the myocardial protectin of crystalloid cardioplegia in infats" Kyobu geka.

Yoshiki Sawa：“晶体停跳液对心肌保护素的临床评估”Kyobu geka。

Yoshiki Sawa: "Ultrastructural assessment of myocardium receing crystalloid cardioplegia in infants" Circulation.

Yoshiki Sawa：“婴儿接受晶体停跳液的心肌的超微结构评估”循环。

Y.SAWA: Circulation research.

Y.SAWA：循环研究。

澤芳樹: 『胸部外科』.

泽芳树：《胸外科》。