STUDIES FOR ESTABLISHMENT OF PEDIATRIC HEART AND LUNG TRANSPLANTATION IN JAPAN

日本开展儿科心肺移植的研究

• 批准号: 12307027
• 负责人: MATSUDA Hikaru
• 金额: $ 27.54万
• 依托单位: OSAKA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12307027/
• 关键词: HEART TRANSPLANTATION; LUNG TRANSPLANTATION; END-STAGE CARDIAC FAILURE; PULMONARY HYPERTENTION; ORGAN PRESERVATION; CHILDREN; XENOTRANSPLANTATION; CRAFT CORONARY ATHEROSCRELOSIS; 小児循環器疾患; 心臓移植; 肺移植; 心肺移植; 適応基準; 実態調査; 脳死判定基準; 異種移植

As Organ transplantation law prohibits for donation from brain dead children younger than 15 years old, small children had almost no chance to undergo heart or lung transplantation in Japan. In thisstudy, the criteria of indication for heart and lung transplantation in children, how many children required heart or lung transplantation in Japan and prognosis of these children were clarified. Although 30 to 50 children required heart or lung transplantation every year in Japan, only two children underwent heart transplantation and five children underwent living lung transplantation in Japan since the law was issued. Altough more than 40 children tried to undergo heart transplantation in USA, only 22 children underwent heart transplantation and 14 died during waiting since the law was issued. To manage pediatric heart and lung recipients, the immunosuppressive regimen and post-transplant care as well as immunization were also investigated. To expand donor pool for children, heart and lung transplantation from non-heart beating donor or animals and living lung transplantation have been also studied. Brain death criteria In children have been also investigated. In the final year, International symposium for pediatric heart and lung transplantation was held and how to establish for pediatric heart and lung transplantation in Japan was discussed with public. The book about for pediatric heart and lung transplantation was published

由于器官移植法禁止15岁以下脑死亡儿童捐献器官，在日本，年幼的儿童几乎没有机会接受心脏或肺移植。在这项研究中，明确了儿童心肺移植的适应证标准，日本有多少儿童需要进行心肺移植，以及这些儿童的预后。虽然日本每年有30到50名儿童需要心脏或肺移植，但自该法律颁布以来，日本只有两名儿童接受了心脏移植，五名儿童接受了活体肺移植。尽管美国有40多名儿童试图接受心脏移植，但自该法律颁布以来，只有22名儿童接受了心脏移植，14名儿童在等待期间死亡。为了管理儿科心肺移植受者，还对免疫抑制方案、移植后护理以及免疫进行了调查。为了扩大儿童的供体储备，还研究了非心脏跳动供体或动物的心肺移植和活体肺移植。还对儿童脑死亡标准进行了调查。在最后一年，召开了儿童心肺移植国际研讨会，并与公众讨论了如何在日本建立儿童心肺移植。关于儿科心肺移植的书出版了

项目成果

Kawauchi M, et al.: "Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primate"Circulation Research. 87・11. 1063-1068 (2000)

Kawauchi M 等人：“通过 HVJ-AVE 脂质体方法在小鼠和非人灵长类动物中使用离体 E2F 诱饵转染来减轻心脏同种异体移植动脉病的基因治疗”循环研究 87·11（2000）。

Kawauchi M, et al.: "Gene therapy for attenuating cardiac allograft arteriopathy using ex vivo E2F decoy transfection by HVJ-AVE-liposome method in mice and nonhuman primates"Circulation Research. 87・11. 1063-1068 (2000)

Kawauchi M 等人：“通过 HVJ-AVE 脂质体方法在小鼠和非人灵长类动物中使用离体 E2F 诱饵转染来减轻心脏同种异体移植动脉病的基因治疗”循环研究 87·11（2000）。

H Matsuda, N Fukushima: "Heart transplantation"Pediatric Medicine. 34. 63-68 (2002)

H Matsuda，N Fukushima：“心脏移植”儿科医学。

T.Matsuishi, et al.: "Brain death in children"Pediatrics. 44. 880-887 (2001)

T.Matsuishi 等人：“儿童脑死亡”儿科。

Hirata T,Fukuse T, et al.: "Reperfusion lung injury after cold preservation correlates with decreased level of intrapulmonary high-energy phosphates."Transplantation. 69(9). 1793-1801 (2000)

Hirata T、Fukuse T 等人：“冷保存后的再灌注肺损伤与肺内高能磷酸盐水平降低相关。”移植。