STUDIES FOR ESTABLISHMENT OF PEDIATRIC HEART AND LUNG TRANSPLANTATION IN JAPAN

由于《器官移植法》禁止15岁以下的脑死亡儿童捐献器官，因此在日本，小孩子几乎没有机会接受心脏或肺移植手术。本研究明确了儿童心肺移植的适应证标准，日本有多少儿童需要进行心肺移植，以及这些儿童的预后。虽然日本每年有30 ~ 50名儿童需要心脏或肺移植，但自该法颁布以来，日本只有2名儿童接受了心脏移植，5名儿童接受了活体肺移植。在美国，虽然有40多名儿童试图接受心脏移植，但自该法颁布以来，只有22名儿童接受了心脏移植，14名儿童在等待过程中死亡。为了管理儿童心肺受者，还调查了免疫抑制方案和移植后护理以及免疫接种。为扩大儿童供体库，还研究了非心脏供体或动物的心肺移植和活体肺移植。对儿童脑死亡标准也进行了调查。最后一年，举办了儿童心肺移植国际研讨会，并与公众讨论了如何在日本建立儿童心肺移植。关于小儿心肺移植的书出版了

As Organ transplantation law prohibits for donation from brain dead children younger than 15 years old, small children had almost no chance to undergo heart or lung transplantation in Japan. In thisstudy, the criteria of indication for heart and lung transplantation in children, how many children required heart or lung transplantation in Japan and prognosis of these children were clarified. Although 30 to 50 children required heart or lung transplantation every year in Japan, only two children underwent heart transplantation and five children underwent living lung transplantation in Japan since the law was issued. Altough more than 40 children tried to undergo heart transplantation in USA, only 22 children underwent heart transplantation and 14 died during waiting since the law was issued. To manage pediatric heart and lung recipients, the immunosuppressive regimen and post-transplant care as well as immunization were also investigated. To expand donor pool for children, heart and lung transplantation from non-heart beating donor or animals and living lung transplantation have been also studied. Brain death criteria In children have been also investigated. In the final year, International symposium for pediatric heart and lung transplantation was held and how to establish for pediatric heart and lung transplantation in Japan was discussed with public. The book about for pediatric heart and lung transplantation was published