ANALYSIS OF PURE PANCREATIC JUICE IN PANCREATIC DISEASES AND ITS CLINICAL SIGNIFICANCE
纯胰汁治疗胰腺疾病的分析及其临床意义
基本信息
- 批准号:61480188
- 负责人:
- 金额:$ 3.52万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (B)
- 财政年份:1986
- 资助国家:日本
- 起止时间:1986 至 1987
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We determined lactoferrin (LF) levels by EIA, as well as conventional parameters in endoscopically aspirated pancreatic juice (PJ), and evaluated the protein plug (PP) in PJ. Furthermore, cancer-associated carbohydrate antigens in PJ were measured, and immunohistochemical staining of pancreatic specimens was performed using antibodies. The results are summerzied as follows.Abnormaly high levels of LF in PJ were observed in 46% of the patients with chronic pancreatitis (CP), with the prevalence being significantly higher in calcified CP 82%) than in non-calcified CP (37%). Moreover, LF levels in PJ rose with the severity of CP. As PP in PJ was found in 55% of the patients with CP,but not in those with other diseases except for pancreatic cancer (8%), PP was considered to be relatively specific for CP. PP in PJ was observed more frequently in calcified CP (82%) than in non-calcified CP (55%). However, significant differences of abnormalires in pancreatogam and pancreatic function were no … More t observed between presence and absence of PP. Mean value and pevalence of abnormal LF in PJ in CP were higher in the PP positive group than in the PP-negative group. Concentration of CA 19-9 in PJ was significantly higher not only in pancreatic cancer (PC) but also in CP, and its prevalence was 92% in PC and 85% in CP. CA 19-9 in PJ in pj was considered to be a sensitive marker for non-specific pancreatic injury, but not for tumors. Concentrations of ST-439 and SLX in PJ were significantly increased only in PC, and their prevalences were 57% and 40%, respectively. They have high tumor-specificity, but their incidence was relatively low. CA 19-9 and CA-50, which are the type 1 chain carbohydrate antigens, were strongly expressed in pancreatic cancer, but were low in cancerspecificity. However, type 2 chain carbohydrate antigens such as CSLEX-1 and SLX showed highest tumor-secificity among the antigens, whereas their incidences were lower than other antigens. On the other hand, ST-439 and DU-PAN-2 exhibited high positivity and specificity. CA 19-9 was strongly and widely distributed mainly in the proliferative small pancreatic duct of CP. This may reflect the increased levels of CA 19-19 in PJ of patients with CP. Less
我们通过EIA测定了乳铁蛋白(LF)水平,以及内镜抽吸的胰液(PJ)中的常规参数,并评估了PJ中的蛋白质栓(PP)。此外,测量PJ中的癌症相关碳水化合物抗原,并使用抗体对胰腺标本进行免疫组织化学染色。结果表明:46%的慢性胰腺炎(CP)患者PJ中LF水平异常增高,钙化CP中LF水平异常增高的发生率(82%)明显高于非钙化CP(37%)。此外,PJ的LF水平随着CP的严重程度而升高。由于55%的CP患者出现PJ中的PP,而除胰腺癌(8%)外,其他疾病患者均未出现PP,因此认为PP对CP具有相对特异性。PJ中的PP在钙化CP中(82%)比在非钙化CP中(55%)更常见。而胰管和胰腺功能异常组间无显著性差异 ...更多信息 在存在和不存在PP之间观察到t。CP患者PJ区LF异常的平均值和发生率在PP阳性组均高于PP阴性组。CA 19-9在PJ中的表达不仅在胰腺癌(PC)中明显增高,在CP中也明显增高,其阳性率分别为92%和85%。PJ中的CA 19-9被认为是非特异性胰腺损伤的敏感标志物,但不是肿瘤。ST-439和SLX在PJ中的浓度仅在PC中显著升高,其患病率分别为57%和40%。它们具有较高的肿瘤特异性,但其发生率相对较低。CA 19-9和CA-50是1型糖链抗原,在胰腺癌中呈强表达,但肿瘤特异性低。而2型糖链抗原如CSLEX-1和SLX的肿瘤特异性最高,但其发生率低于其他抗原。ST-439和DU-PAN-2则具有较高的阳性率和特异性。CA 19-9主要分布于CP增生的小胰管中。这可能反映了CP患者PJ中CA 19-19水平的升高。少
项目成果
期刊论文数量(31)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
NORIO SAWABU,ET AL: "DIAGNOSTIC AVAILABILITY OF CANCER-ASSOCIATED CARBOHYDRATE ANTIGENS" JPN. J. CANCER CHEMOTHER. 15. 1091-1101 (1988)
NORIO SAWABU 等人:“癌症相关碳水化合物抗原的诊断可用性”JPN。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
澤武紀雄 他: "臨床検査Mook.膵疾患の検査,Tumor marker" 金原出版, 16 (1987)
Takeo Sawa等:“临床检查Mook.胰腺疾病的检查、肿瘤标志物”Kanehara Publishing,16(1987)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
澤武紀雄 他: "Annual Review消化器消化器疾患の腫瘍マーカー" 中外医学社, 7 (1988)
Takeo Sawa 等人:“胃肠道疾病肿瘤标志物年度回顾”Chugai Igakusha,7 (1988)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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SAWABU NORIO的其他文献
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