Chronic Pancreatitis, Diabetes and Pancreatic Cancer: A Prospective Approach

慢性胰腺炎、糖尿病和胰腺癌：前瞻性方法

• 批准号: 9150621
• 负责人: Stephen K. Van Den Eeden
• 金额: $ 40.39万
• 依托单位: KAISER FOUNDATION RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-28 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9150621
• 关键词: Abdomen; Alcohol consumption; Algorithms; Area; Back Pain; California; Chronic; Clinical; Clinical Research; Collaborations; Computerized Medical Record; Data; Data Coordinating Center; Data Quality; Diabetes Mellitus; Diagnosis; Disease; Endocrine; Epidemiology; Etiology; Exocrine pancreatic insufficiency; Family; Family history of; Functional disorder; Genetic Predisposition to Disease; Genetic study; Health; Individual; Inflammation; Inflammatory; Inherited; Interview; Knowledge; Lead; Left; Lesion; Link; Malignant neoplasm of pancreas; Metabolic; Mutation; Nature; Outcome; Pain; Pancreas; Pancreatitis; Patients; Peptide Hydrolases; Pilot Projects; Prediabetes syndrome; Prevention strategy; Process; Protocols documentation; Quality of life; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Methodology; Resources; Risk Estimate; Sampling; Symptoms; Techniques; Testing; Time; Tissues; Trauma; Work; biomarker development; chronic pancreatitis; cohort; data management; design; diabetes risk; exome sequencing; follow-up; high risk; innovation; kindred; novel; outcome forecast; predictive modeling; programs; prospective; response; treatment strategy

 DESCRIPTION (provided by applicant): This application, in response to RFA-DK-14-007, seeks to advance the opportunities to study how chronic pancreatitis, pre-diabetes, diabetes and pancreatic cancer are related to each other. We seek to contribute to the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CSCPDPC) by bringing expertise, unique data and innovative proposed studies together to be part of this collaborative effort. We propose to develop the infrastructure to work with the CSCPDPC, conduct analyses directed at estimating the risk of type 3c diabetes mellitus (T3cDM) and/or pancreatic cancer associated with having chronic pancreatitis, develop two algorithms to identify patients with chronic pancreatitis at high risk of T3cDM and/or pancreatic cancer from electronic medical records, use the algorithms to identify, recruit and follow an inception cohort of 600 high risk individuals and to conduct a pilot genetic study of chronic pancreatitis. We believe our proposed research program conducted in collaboration with the other Clinical Centers and the Coordination and Data Management Center (CDMC) will advance our basic knowledge and lead to better prevention and treatment strategies.

 描述（由申请人提供）：本申请是对RFA-DK-14-007的回应，旨在促进研究慢性胰腺炎、糖尿病前期、糖尿病和胰腺癌之间相互关系的机会。我们寻求为慢性胰腺炎，糖尿病和胰腺癌研究联盟（CSCPDPC）做出贡献，将专业知识，独特的数据和创新的拟议研究结合在一起，成为这一合作努力的一部分。我们建议开发与CSCPDPC合作的基础设施，进行旨在估计与慢性胰腺炎相关的3c型糖尿病（T3 cDM）和/或胰腺癌风险的分析，开发两种算法来识别患有慢性胰腺炎的患者T3 cDM和/或电子病历中的胰腺癌风险，使用算法来识别，招募并跟踪600名高风险个体的初始队列，并进行慢性胰腺炎的初步遗传研究。我们相信，我们与其他临床中心和协调与数据管理中心（CDMC）合作开展的拟议研究计划将促进我们的基本知识，并导致更好的预防和治疗策略。