Experimental and clinical studies on low osmolality contrast media.

低渗透压造影剂的实验和临床研究。

• 批准号: 61480234
• 负责人: SUZUKI Soji
• 金额: $ 4.03万
• 依托单位: Tokyo Medical & Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1986
• 资助国家: 日本
• 起止时间: 1986 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-61480234/
• 关键词: Osmotic Pressure; low Osmolality Contrast Media; Hemodynamics; 末梢動脈撮影; 造影剤の浸透圧

Experimental StudyThe changes of the mean blood flow rates at two different levels, the femoral and dorsalis pedis arteries, of the hind leg of the dog following injections of glucose solutions of various concentrations (5% to 50%) and four kinds of contrast media were investigated by means of an electromagnetic flowmeter. Based upon the experiment, the low osmolality contrast media should be considered superior to the conventional high osmolality contrast media for arteriography of the lower extremities from the hemodynamic point of view, since the vascular bed in the proximal part of the limbs was dilated to a lesser degree, and more efficient utilization in demonstration of arteries in the distal part of the limbs could be expected by using low osmolality contrast media.Clinical StudyAn ideal programming of x-ray exposures and step-sliding of the table- top was obtained based upon the sequential analysis of the contrast column passing through the arteries of the lower extremities in serial whole-limb angiography performed in patients with non-occlusive as well ad occlusive arterial disease of the lower extremities. A series of 131 aortofemoral angiographies using low osmolality contrast media and the above programming were performed and an excellent angiogram visualizing the abdominal aorta down to arteries of the feet could be obtained in all cases.

实验研究用电磁流量计研究了不同浓度葡萄糖溶液（5% ~ 50%）和4种造影剂注射后狗后腿股动脉和足背动脉两个不同水平平均血流速率的变化。根据实验结果，从血流动力学的角度来看，低渗透压造影剂优于传统的高渗透压造影剂用于下肢动脉造影术，因为肢体近端血管床扩张程度较小，使用低渗透压造影剂可以更有效地显示肢体远端动脉。临床研究通过对非闭塞性和闭塞性下肢动脉疾病患者全肢血管造影中造影柱穿过下肢动脉的序列分析，得到了理想的x线曝光和桌面台阶滑动规划。使用低渗透压造影剂和上述程序进行了一系列131次主动脉血管造影，所有病例都可以获得良好的血管造影，显示腹主动脉至足动脉。

项目成果

佐藤史郎: 脈管学. 26. 1143-1151 (1986)

佐藤四郎：血管学。26。1143-1151（1986）

Suzuki,Soji: "Low Osmolality Contrast Media in Excretory Urography" Jpn. J. Clin. Radiol.32. 253-262 (1987)

Suzuki，Soji：“排泄性尿路造影中的低渗透压造影剂”Jpn。

唐沢秀治: Neuroradioloqy. 29. 36-39 (1987)

唐泽英晴：神经放射学。29. 36-39 (1987)

Okada,Yoichi: "Hemodynamic Changes in Femoral and Dorsalis Pedis Arteries following Injections of Glucose Solutions and Contrast Media in the Dog." Nippon Acta radiol.47. 931-938 (1987)

冈田阳一：“在狗身上注射葡萄糖溶液和造影剂后股动脉和足背动脉的血流动力学变化。”

佐藤史郎: 画像診断. 6. 355-361 (1986)

佐藤四郎：影像诊断。6. 355-361 (1986)。