Experimental and clinical studies on low osmolality contrast media.

实验研究用电磁流量计观察了犬后腿注射不同浓度葡萄糖溶液(5%~50%)和4种造影剂后，股动脉和足背动脉两个不同水平的平均血流速度的变化。根据实验结果，从血流动力学角度考虑，由于肢体近端的血管床扩张程度较轻，低渗造影剂比常规的高渗造影剂更适用于下肢动脉造影。临床研究通过对非闭塞性和非闭塞性下肢动脉疾病患者连续行全肢血管造影术的对比柱序列分析，获得了理想的X线片曝光和台面滑动程序。应用低渗造影剂和上述程序进行了131例主-股动脉血管造影，所有病例均可获得良好的腹主动脉至足部动脉的血管成像。

Experimental StudyThe changes of the mean blood flow rates at two different levels, the femoral and dorsalis pedis arteries, of the hind leg of the dog following injections of glucose solutions of various concentrations (5% to 50%) and four kinds of contrast media were investigated by means of an electromagnetic flowmeter. Based upon the experiment, the low osmolality contrast media should be considered superior to the conventional high osmolality contrast media for arteriography of the lower extremities from the hemodynamic point of view, since the vascular bed in the proximal part of the limbs was dilated to a lesser degree, and more efficient utilization in demonstration of arteries in the distal part of the limbs could be expected by using low osmolality contrast media.Clinical StudyAn ideal programming of x-ray exposures and step-sliding of the table- top was obtained based upon the sequential analysis of the contrast column passing through the arteries of the lower extremities in serial whole-limb angiography performed in patients with non-occlusive as well ad occlusive arterial disease of the lower extremities. A series of 131 aortofemoral angiographies using low osmolality contrast media and the above programming were performed and an excellent angiogram visualizing the abdominal aorta down to arteries of the feet could be obtained in all cases.