Experimental and clinical studies on hemodynamic effects of low osmolality contrast media on the arteries of the limbs

实验研究：观察利多卡因对8只犬股动脉和足背动脉血流的影响。注射0.2、1.0和2.0 mg/kg体重的利多卡因可显著提高股动脉血流速度。注射这些利多卡因溶液后血流速度的增加在模式上与注射造影剂非常相似。达到峰值的时间。然而，在高渗透压造影剂中，达到峰值的时间明显长于利多卡因溶液。结论：动脉内注射高渗透压造影剂后血流增加，应为继发于短暂缺血的反应性充血。临床研究：在血管造影术和经皮冠状动脉成形术中，对肢体皮肤进行了激光多普勒血流检测。血流量计法证实动脉注射造影剂(低渗透造影剂)可增加皮肤毛细血管的血流量。激光多普勒流量计PeriFlux PF3(Perimed)可对PTA进行实时评价。

Experimental study: The effects of lidocaine on the blood flow in the femoral and dorsalis pedis arteries were investigated in eight dogs. The blood flow rate in the femoral artery was significantly elevated by an injection of 0.2, 1.0 or 2.0 mg/kg body weight of lidocaine. The increase in the blood flow rate following the injection of those lidocaine solutions was quite similar in pattern to the injection of contrast media. The time to reach the peak .however, was significantly longer in high osmolality contrast medium than lidocaine solution. It was concluded that the increase of the blood flow following intra-arterial injection of high osmolality contrast media should be reactive hyperemia secondary to momentary ischemia caused by the media.Clinical study:The laser Doppler flowmetry on the skin of the lower extremities has been performed during angiography and PTA. The blood flow through the capillaries of the skin was proven to be elevated by intraarterial injection of contrast media (low osmolality contrast media) by the flowmetry. The real-time evaluation of the PTA could be obtained by the laser Doppler flowmeter PeriFlux PF3, Perimed ).