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Correlation between concommitant immunity and postoperative recurrence in primary resected lung cancers

原发性肺癌切除术后伴随免疫与复发的相关性

基本信息

批准号：
61480293
负责人：
FUJISAWA Takehiko
金额：
$ 4.16万
依托单位：
Chiba University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1988
项目状态：
已结题

项目摘要

The objective of this study is to demonstrate the correlation between cytotoxic activity against autologous tumor cells and postoperative recurrence in primary resected lung cancers. Autologus tumor cells were cultured by the specimens oftained from primary sites and peripheral blood lymphocytes were separated by Ficoll-Hypaqye discontunuous gradient and utilized as effectors to measure postoperative cytotoxic activity. The rusults obtained herein are as follows:1) Overall cytotoxic activities against autologous tumor cells ranged from -3.9-39.6% with an average of 16.1%, and the average cytotoxic activities against established lung adenocarcinoma cell line PC-3 and leukemia cell line K562 were 29.6% and 46.5%, respectiyely. No statistically significant changes of cytotoxic activities against these 3 targets to stages or resectabilities were demonstrated, but there existed some differences between histologic types, that is, the cytotoxic activity against autologous tumor cells in adeno … More carcinoma tend to be higher than that of squamous cell carcinoma (P<0.1 by Student t test)2) When the cytotoxic activity against autologous tumor cells in adenocarcinoma was evaluated by stages, the value of stage I was significantly higher than that of stage IV(P<0.05 by Student t test), however, there were no significant changes between any stages in squamous cell carcinoma. Furthermore, no statistically significant differences between any stages in the cytotoxic activities against PC-3 or K562 targets of adenocarcinoma were demonstrated.3) In patients given a complete resection, the cytotoxic activity against the autologous tumor cells during the postoperative 1-2 weeks was significantly higher than during the postoperative 4-5 weeks (P<0.05, Student t test). In patients given an incomplete resection, however, no significant difference was demonstrated between the postoperative 1-2 weeks and during the postoperative 4-5 weeks.4) In contrast, the cytotoxic activity against the PC-3 cells or K562 cells during the postoperative 4-5 weeks tended to rise in comparison to those at the postoperative 1-2 weeks all patients in any cancer stage and whatever the amount of their lung resection.From these rusults, we conclude that there may exist a concommitant immunity in primary lung cancers, and that ATCA appears to be a good prognostic parameter in lung cancers, particularly adenocarcinomas. Less

本研究的目的是证明对自体肿瘤细胞的细胞毒活性与原发性切除肺癌术后复发之间的相关性。采用Ficoll-Hypaqye不连续梯度离心法分离外周血淋巴细胞，作为效应细胞，测定术后细胞毒活性。结果表明：（1）对自体肿瘤细胞的总细胞毒活性为-3.9-39.6%，平均为16.1%，对已建立的肺腺癌细胞系PC-3和白血病细胞系K562的平均细胞毒活性分别为29.6%和46.5%。对这3个靶点的细胞毒活性在不同分期或可切除性之间没有统计学显著性变化，但在不同组织学类型之间存在一些差异，即对腺样囊性癌中自体肿瘤细胞的细胞毒活性在不同的组织学类型之间存在差异。 ...更多信息 2）按分期评价腺癌对自体肿瘤细胞的杀伤活性时，Ⅰ期显著高于Ⅳ期（P <0.05），而鳞癌各期之间无显著性差异。此外，对腺癌PC-3或K562靶点的细胞毒活性在任何阶段之间均无统计学显著差异。3）在完全切除的患者中，术后1-2周对自体肿瘤细胞的细胞毒活性明显高于术后4-5周（P<0.05，Student t检验）。然而，在给予不完全切除的患者中，术后1-2周与术后4-5周之间没有显著差异。术后4-5周对PC-3细胞或K562细胞的细胞毒活性与术后1 - 5周相比有上升趋势。结果表明，原发性肺癌患者可能存在一种伴随免疫，ATCA是肺癌，尤其是腺癌的一个良好的预后指标。少

项目成果

期刊论文数量（48）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

藤沢武彦、深沢敏男、斉藤幸雄、卜部憲和、野本靖史、山川久美、馬場雅行、木村秀樹、山口豊: Oncologia. 21. 99-105 (1988)

Takehiko Fujisawa、Toshio Fukasawa、Yukio Saito、Norikazu Urabe、Yasushi Nomoto、Kumi Yamakawa、Masayuki Baba、Hideki Kimura、Yutaka Yamaguchi：肿瘤学。 21. 99-105 (1988)

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0
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山口豊;藤沢武彦;斉藤博明: MedicalPractice. 3. 2002-2006 (1986)

山口裕；藤泽雄彦；斋藤弘明：《医学实践》3. 2002-2006 (1986)

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0
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T.Fujisawa;Y.Yamaguchi;H.Saitoh: "Proceedings of fifth International Workshop on Transfer Factor" Slovok Academy of Science, (1987)

T.Fujisawa;Y.Yamaguchi;H.Saitoh：“第五届转移因子国际研讨会论文集”，斯洛伐克科学院，（1987 年）

DOI：
发表时间：
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影响因子：
0
作者：
通讯作者：

藤沢武彦、深沢敏男、斉藤幸雄、ト部憲和、野本靖史、山川久美、馬場雅行、木村秀樹、山口豊: 癌の臨床. 34. 1922-1926 (1988)

Takehiko Fujisawa、Toshio Fukasawa、Yukio Saito、Norikazu Tobe、Yasushi Nomoto、Kumi Yamakawa、Masayuki Baba、Hideki Kimura、Yutaka Yamaguchi：临床癌症。 1922-1926 (1988)。