Extracorpoteal Lung Assist for Neonatal Respiratory Failure

本文研究了一种新型的V-V旁路体外肺辅助（ECLA as ECMO）系统，并对6只胎龄为118[139天的剖宫产早产山羊作为婴儿呼吸功能不全的实验模型进行了疗效研究，然后将其应用于一名因机械肺通气而发生危及生命的气压损伤的早产儿。控制体外旁路流量和人工膜肺气体流量，使PaO_2保持在40mmHg以上，PaCO_2保持在正常范围内。新生儿自己的肺。持续气道正压5 [12cm H_2O， IMV无氧供氧。两只体重分别为1250g和700g的山羊出生后2.5小时出现严重循环窘迫。但其余4例体重大于2000g的患儿均成功脱离%eCLA，其中3例也可脱离机械通气。人类婴儿也存活下来，并于第三天从ECLA断奶。

A mew to-and fro V-V bypass extracorporeal lung assist(ECLA as ECMO) system was developed and investigated for its efficacy on six premature goats delivered by Cesarean section at a gestational age of 118 [139 days as an experimental model of infant fespiratory insufficiency, then applied to a human premature infant suffering from life threatening barotrauma developed from mechanical pulmonary ventilation. The extracorporeal bypass flow and gas flow to the artificial membrane lung were controlled to keep PaO_2 above 40mmHg and PaCO_2 within normal limits. The newborn' own lungs.were treated with a continuous positive airway pressure of 5 [12 cm H_2O, apneic oxygenation of IMV. Two goats weighting 1250g and 700g 2 [2.5 hours after birth from severe circulatory distress. However, other four cases, heavier than 2000g, were successfully weaned from %eCLA, and three of them could be weaned from mechanical ventilation as well. The humam infant also survived and weaned from ECLA on the third day.