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DEVELOPMENT OF A MANUALLY OPERATED PORTABLE CARDIOPULMONARY BYPASS FOR EMERGECY RESUSCITATION

用于紧急复苏的手动便携式心肺转流器的开发

基本信息

批准号：
04557070
负责人：
TERASAKI Hidenori
金额：
$ 9.15万
依托单位：
KUMAMOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

项目摘要

Recent success using emergency percutaneous cardiopulmonary bypass as a tool for resuscitation from cardiac arrest is very encouraging. However even a portable bypass machine is still large and heavy to be immediately transported to a patient. It needs also many man powers, special technique, and electricity. Advantages of cardiopulmonary bypass have remained limited. To facilitate this time consuming process, we developed a manually operated portable cardiopulmonary bypass system for emergency resuscitation. The device is composed of two self-inflating silicone ballon pumps with four one-way valves and a compact artificial lung. The priming volume of the circuit is about 450 ml, and the total weight of the primed device is less than 2 kg. By manual compression of the two silicone ballon pumps alternatively, the blood returns into the femoral artery through the artificial membrane lung, and the venous blood drained out simultaneously by self-inflating of one of the reservoir pumps. The device can provide the blood flow rate of 2.5-3.1L/min at maximum.We applied this method to resuscitate an induced cardiac arrest by electric current in 9 dogs. During a period of cardiac arrest of 15 to 30 min, dogs were supported with the manually operated cardiopulmonary bypass. All of 9 dogs recovered completely without neurological sequelae. This innovation will improve the survival rate of cardiopulmonary cerebral resuscitation.

最近使用紧急经皮心肺转流术作为心脏骤停复苏工具的成功非常令人鼓舞。然而，即使是便携式旁路机仍然又大又重，无法立即运送到患者身边。它还需要大量的人力、特殊技术和电力。体外循环的优势仍然有限。为了促进这一耗时的过程，我们开发了一种用于紧急复苏的手动操作便携式心肺旁路系统。该装置由两个带有四个单向阀的自充气硅胶球泵和一个紧凑的人工肺组成。该回路的引水体积约为450毫升，引水装置的总重量小于2公斤。通过手动交替压缩两个硅胶球囊泵，血液通过人工膜肺返回股动脉，同时通过其中一个储液泵的自动充气将静脉血排出。该装置最大可提供2.5-3.1L/min的血流量。我们应用该方法对9只狗进行了电流诱导心脏骤停的复苏。在 15 至 30 分钟的心脏骤停期间，狗通过手动操作的体外循环得到支持。 9只狗全部康复，没有出现神经系统后遗症。这一创新将提高心肺脑复苏的存活率。