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DEVELOPMENT OF A MANUALLY OPERATED PORTABLE CARDIOPULMONARY BYPASS FOR EMERGECY RESUSCITATION

用于紧急复苏的手动便携式心肺转流器的开发

基本信息

批准号：
04557070
负责人：
TERASAKI Hidenori
金额：
$ 9.15万
依托单位：
KUMAMOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

项目摘要

Recent success using emergency percutaneous cardiopulmonary bypass as a tool for resuscitation from cardiac arrest is very encouraging. However even a portable bypass machine is still large and heavy to be immediately transported to a patient. It needs also many man powers, special technique, and electricity. Advantages of cardiopulmonary bypass have remained limited. To facilitate this time consuming process, we developed a manually operated portable cardiopulmonary bypass system for emergency resuscitation. The device is composed of two self-inflating silicone ballon pumps with four one-way valves and a compact artificial lung. The priming volume of the circuit is about 450 ml, and the total weight of the primed device is less than 2 kg. By manual compression of the two silicone ballon pumps alternatively, the blood returns into the femoral artery through the artificial membrane lung, and the venous blood drained out simultaneously by self-inflating of one of the reservoir pumps. The device can provide the blood flow rate of 2.5-3.1L/min at maximum.We applied this method to resuscitate an induced cardiac arrest by electric current in 9 dogs. During a period of cardiac arrest of 15 to 30 min, dogs were supported with the manually operated cardiopulmonary bypass. All of 9 dogs recovered completely without neurological sequelae. This innovation will improve the survival rate of cardiopulmonary cerebral resuscitation.

最近成功地使用紧急经皮体外循环作为心脏骤停复苏的工具是非常令人鼓舞的。然而，即使是便携式搭桥机也仍然又大又重，无法立即运送到患者手中。它还需要许多人力、特殊技术和电力。体外循环的优势仍然有限。为了方便这一耗时的过程，我们开发了一种用于紧急复苏的手动便携式体外循环系统。该装置由两个带有四个单向阀的自充式硅胶气囊泵和一个紧凑的人工肺组成。该电路的起爆量约为450毫升，起爆装置的总重量不到2公斤。通过交替手动压缩两个硅胶气囊泵，血液通过人工膜肺返回股动脉，静脉血通过其中一个储液泵的自充气同时排出。该装置最高可提供2.5-3.1L/min的血流速度。我们应用这种方法复苏了9只犬的一次电流诱导的心脏骤停。在15~30min的心脏骤停期间，犬采用手动体外循环。9只犬全部痊愈，无神经后遗症。这一创新将提高心肺脑复苏的存活率。