EFFECTS OF HYPOTHERMIC EXTRACORPOREAL LUNG AND HEART ASSIST (ECLHA) ON CARDIOPULMONARY AND CEREBRAL RESUSCITATION

低温体外肺心辅助 (ECLHA) 对心肺和脑复苏的影响

基本信息

  • 批准号:
    11470325
  • 负责人:
  • 金额:
    $ 8.77万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B).
  • 财政年份:
    1999
  • 资助国家:
    日本
  • 起止时间:
    1999 至 2000
  • 项目状态:
    已结题

项目摘要

Background and purpose : Although normothermic extracorporeal lung and heart assist (ECLHA) improves cardiac outcomes, patients can not benefit from hypothermia-mediated brain protection. The present study evaluated the effects of long-term ECLHA with mild to moderate hypothermia (33℃) in a canine model of prolonged cardiac arrest.Methods : Fifteen dogs were assigned to either the hypothermic (7 dogs, 33℃) or normothermic group (8 dogs, 37.5℃). All dogs were induced to normothermic ventricular fibrillation (VF) for 15 min, followed by 24 h of ECLHA and 72 h of intensive care. The hypothermia group maintained core (pulmonary artery) temperature at 33℃ for 20 h starting from resuscitation, then were rewarmed by 28 h. Outcome evaluations included : 1. mortality, 2. catecholamine dose, 3. time to extubation, 4. necrotic myocardial mass (g), 5. Neurological Deficits Score (NDS).Results : In the normothermic group 4 dogs died of cardiogenic shock and 1 dog succumbed to poor oxygenation. The 2 surviving dogs remained comatose (NDS 60.5 ± 4.9%) with necrotic myocardial mass of 14.5 ± 3.5 g. In the hypothermic group, one dog died from pulmonary dysfunction, the other 6 dogs survived. The surviving dogs showed brain damage (29.8 ± 2.5%), but there was evidence of some brain-protective effect. The mass of necrotic myocardium was 4.2 ± 1.3 g in the hypothermic group or 3.4 times smaller than in the normothermic group. The survival rate was significantly higher in the hypothermic than in the normothermic group (P<0.01). The catecholamine requirement was also lower in the hypothermic than in the normothermic dogs (P<0.05).Conclusions : Long-term mild to moderate hypothermia with ECLHA induced immediately after cardiac arrest improved survival as well as cerebral and cardiac outcomes.
背景和目的:尽管常温体外心肺辅助(ECLHA)可以改善心脏功能,但患者并不能从低温介导的脑保护中受益。方法:15只犬随机分为亚低温组(7只,33℃)和常温组(8只,37.5℃)。所有犬均诱发常温室颤(VF)15min,然后进行ECLHA治疗24 h和重症监护72 h。结果:常温组4只犬死于心源性休克,1只犬死于低氧。结果:1.死亡率,2.儿茶酚胺用量,3.拔管时间,4.坏死性心肌质量(G),5.神经功能障碍评分(NDS)。结果:常温组4只犬死于心源性休克,1只犬死于低氧合。存活的2只犬仍处于昏迷状态(NDS 60.5±4.9%),心肌坏死质量为14.5±3.5g,亚低温组1只犬死于肺功能障碍,其余6只存活。存活犬出现脑损伤(29.8±2.5%),但有一定的脑保护作用。亚低温组坏死区心肌质量为4.2±1.3g,比常温组小3.4倍。亚低温组的存活率显著高于常温组(P&lt;0.01)。低温组的儿茶酚胺需要量也低于常温组(P&lt;0.05)。结论:在心脏骤停后立即行ECLHA的长期亚低温可以改善患者的存活率以及脑心功能。

项目成果

期刊论文数量(32)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Ao H,Tanimoto H,Yositaka A,Moon JK,Terasaki H: "Long term mild hypothermia with ECLHA improved survival in prolonged cardiac arrest dogs"Resuscitation. 48・. 163-174 (2001)
Ao H、Tanimoto H、Yositaka A、Moon JK、Terasaki H:“ECLHA 的长期轻度低温改善了长时间心脏骤停狗的存活率”48·163-174 (2001)。
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Sakanashi Y, Tanimoto H, Okamoto T, Tashiro M, Ao H and Terasaki H: "Total and prolonged filling of the lungs with Ringer's solution under extracorporeal lung assist (ECLA) in dogs."Acta Anesthesiologica Scandinavica. 44. 994-1001 (2000)
Sakanashi Y、Tanimoto H、Okamoto T、Tashiro M、Ao H 和 Terasaki H:“在体外肺辅助 (ECLA) 下,狗的肺部完全且长时间地充满林格液。”Acta Anesthesiologica Scandinavica。
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    0
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Ao H, Tanimoto H, Yositake A, Moon JK and Terasaki H: "Heparin bonded extracorporeal circuit reduces thrombosis during prolonged lung assist in goats."American Society for Artificial Internal Organs Journal. 46. 723-729 (2000)
Ao H、Tanimoto H、Yositake A、Moon JK 和 Terasaki H:“肝素结合的体外回路可减少山羊长期肺辅助过程中的血栓形成。”美国人工内脏器官学会杂志。
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    0
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Sakanashi Y,Tanimoto H,Okamoto T,Tashiro M,Ao H,Terasaki H: "Total and prolonged filling of the lungs with Ringer's solution under extracorporeal lung assist (ECLA) in dogs"Acta Anesthesiologica Scandinavica. 44・. 994-1001 (2000)
Sakanashi Y、Tanimoto H、Okamoto T、Tashiro M、Ao H、Terasaki H:“体外肺辅助 (ECLA) 下狗的肺部完全和长时间充盈”Acta Anesthesiologica Scandinavica 44·。 2000)
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    0
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  • 通讯作者:
Ao H, Tanimoto H, Yositake A, Moon JK and Terasaki H: "Long term mild hypothermia with ECLHA improved survival in prolonged cardiac arrest dogs."Resuscitation. 48. 163-174 (2001)
Ao H、Tanimoto H、Yositake A、Moon JK 和 Terasaki H:“ECLHA 的长期轻度低温改善了长时间心脏骤停狗的存活率。”复苏。
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TERASAKI Hidenori其他文献

Physical Properties and Composition of Cores of Terrestrial Planets
类地行星核心的物理性质和成分

TERASAKI Hidenori的其他文献

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{{ truncateString('TERASAKI Hidenori', 18)}}的其他基金

Clarification of phase stability of retained-austenite in M-A constituent by crystallographic analysis using synchrotron radiation.
使用同步辐射进行晶体学分析,澄清 M-A 成分中残留奥氏体的相稳定性。
  • 批准号:
    24560879
  • 财政年份:
    2012
  • 资助金额:
    $ 8.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of neutron tomography under pressure: 3D distribution of fluid in the mantle minerals
压力下中子断层扫描的发展:地幔矿物中流体的 3D 分布
  • 批准号:
    23654181
  • 财政年份:
    2011
  • 资助金额:
    $ 8.77万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
The effect of light elements on density and elastic wave velocity of liquid Fe: Implication to light elements in the Earth's outer core
轻元素对液态铁密度和弹性波速的影响:对地球外核轻元素的影响
  • 批准号:
    23340159
  • 财政年份:
    2011
  • 资助金额:
    $ 8.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
In-situ observation of solidification process of weld by using synchrotron radiation towards construction of simulation model of weld solidification
同步辐射原位观测焊缝凝固过程构建焊缝凝固模拟模型
  • 批准号:
    22760559
  • 财政年份:
    2010
  • 资助金额:
    $ 8.77万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Effects of rapidly induced mild hypothermia with extracorporeal lung and heart assist on the neurological outcome after prolonged cardiac arrest in dogs.
体外肺和心脏辅助快速诱导的轻度低温对狗长时间心脏骤停后的神经系统结果的影响。
  • 批准号:
    15390476
  • 财政年份:
    2003
  • 资助金额:
    $ 8.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
EXTRACORPOREAL LING AND HEART ASSIST COMBINED WITH HYPOTHERMIA FOR BRAIN RESUSCITATION
体外灵和心脏辅助结合低温进行脑复苏
  • 批准号:
    09470331
  • 财政年份:
    1997
  • 资助金额:
    $ 8.77万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Total pulmonary liquid instillation under extracorporeal lung assist in dogs
犬体外肺辅助下全肺液体灌注
  • 批准号:
    05454424
  • 财政年份:
    1993
  • 资助金额:
    $ 8.77万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
DEVELOPMENT OF A MANUALLY OPERATED PORTABLE CARDIOPULMONARY BYPASS FOR EMERGECY RESUSCITATION
用于紧急复苏的手动便携式心肺转流器的开发
  • 批准号:
    04557070
  • 财政年份:
    1992
  • 资助金额:
    $ 8.77万
  • 项目类别:
    Grant-in-Aid for Developmental Scientific Research (B)
Safety and validity of the small heparin-bonded artificial membrance lung for neonatal extracorporeal lung assist.
小型肝素人工膜肺用于新生儿体外肺辅助的安全性和有效性。
  • 批准号:
    03454378
  • 财政年份:
    1991
  • 资助金额:
    $ 8.77万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
SAFETY AND EFFICACY OF A PROLONGED EXTRACORPOREAL LUNG ASSIST WITH A HEPARIN BONDED ARTIFICIAL MEMBRANE LUNG.
使用肝素粘合人工膜肺进行长时间体外肺辅助的安全性和有效性。
  • 批准号:
    63480351
  • 财政年份:
    1988
  • 资助金额:
    $ 8.77万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)

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2/2:儿科院前气道复苏试验 (Pedi-PART)
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