The Similarities and Differences of Biological Markers in Bipolar Disorders and Paranoid Schizophrenia

双相情感障碍和偏执型精神分裂症生物标志物的异同

• 批准号: 62480242
• 负责人: WATANABE Akiko
• 金额: $ 2.24万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480242/
• 关键词: AFFECTIVE DISORDER; PARANOID SCHIZOPHRENIA; BETA-PHENYLETHYLAMINE; IMIPRAMINE BINDING; PAROXETINE BINDING; MONOAMINE OXIDASE; ヒト血小板; ストレス; 双極感情病; 5-HT取り込み; ^3H-imipramine結合; ^3H-paroxetine結合; うつ病血清; 除タンパク血清; 5ーHT取り込み; ^3Hーimipramine結合; ^3H

Urinary beta-phenylethylamine ( PEA ), one of biological markers in both affective disorder and paranoid schizophrenia, was examined in rapid cycler bipolar disorder. Increase in urinary PEA was found preceding the switch from mania to depression. This finding suggests that PEA plays the role of a biological trigger in the switch mechanism of a rapid cycler, especially in the switch from mania to depression. Secondary, we studied the role of PEA in schizophrenia. Schizophrenia was divided into two types : paranoid and non-paranoid. Increased urinary PEA excretion was found only in paranoid schizophrenia. A relationship between platelet monoamine oxidase (MAO) activity and urinary PEA excretion was found. These results suggest that PEA plays different roles in bipolar disorder and schizophrenia.We previously reported the mean maximum number of binding sites (Bmax) of imipramine in depressed patients was significantly lower than that in healthy controls. A significant negative correlation was found between the Bmax values and total scores of the 17-item Hamilton depression rating scale in major depression, but not in bipolar disorder. In this study, we investigated platelet paroxetine binding in bipolar disorder. But, the Bmax of paroxetine binding was not significantly decreased compared to that of healthy controls. The hypothesis that endogenous inhibitors acting on imipramine binding sites was discussed. Then, we studied controls and depressed patients to conform whether the activity of endogenous inhibitors acting on imipramine binding. But inhibition activities of the imipramine and paroxetine by serum from controls and depressed patients were similar.

对快速循环双相情感障碍患者进行尿β-苯乙胺（PEA）检测。尿PEA的增加被发现之前的转换从躁狂症到抑郁症。这一发现表明，PEA在快速循环的转换机制中起着生物触发器的作用，特别是在从躁狂到抑郁的转换中。其次，我们研究了PEA在精神分裂症中的作用。精神分裂症分为偏执型和非偏执型。仅在偏执型精神分裂症中发现尿PEA排泄增加。本研究发现，血小板单胺氧化酶（MAO）活性与尿PEA排泄量有关，提示PEA在双相情感障碍和精神分裂症中起着不同的作用，我们曾报道抑郁症患者丙咪嗪的平均最大结合位点数（Bmax）显著低于健康对照组。重性抑郁症的Bmax值与汉密尔顿抑郁量表总分呈显著负相关，而双相情感障碍的Bmax值与总分无相关性。在这项研究中，我们调查了血小板帕罗西汀结合双相情感障碍。但是，帕罗西汀结合的Bmax与健康对照相比没有显著降低。对内源性抑制剂作用于丙咪嗪结合位点的假说进行了讨论。然后，我们研究了对照组和抑郁症患者，以确定是否内源性抑制剂的活性作用于丙咪嗪结合。而抑郁症患者和正常人血清对丙米嗪和帕罗西汀的抑制活性相似。

项目成果

Yamada,S.,Nankai,M.,Yoshimoto,S.and Takahashi,R.: The Japanese Journal of Psychiatry and Neurology. 42. 675 (1988)

山田，S.，南海，M.，吉本，S.和高桥，R.：日本精神病学和神经病学杂志。

Yamada,S.et al.,: "The relashionship between ^<14>C-5HT uptake and ^3H-paroxetine bindingin the human platelets." The Japanese journal of Psychiatry and Neurrology. 42. 675 (1988)

Yamada，S.et al.，：“人血小板中^14C-5HT摄取与^3H-帕罗西汀结合之间的关系。”

高橋良、他: "躁うつ病、精神分裂病の神経化学-神経伝達物質を中心に-" 日独医報. 33. 319-330 (1988)

Ryo Takahashi 等人：“躁狂抑郁症和精神分裂症的神经化学 - 关注神经递质 -”日德医学杂志 33. 319-330 (1988)。

Semba, J., Nankai, M., Maruyama, Y., Kaneno, S., Watanabe, A., and Takahashi, R.: "Increase in Urinary beta-Phenylethylamine Preceding the Switch from Mania to Depression : A "Rapid Cycler"." Clinical Psychiatry, Vol.176, 116 - 119, 1988.

Semba, J.、Nankai, M.、Maruyama, Y.、Kaneno, S.、Watanabe, A. 和 Takahashi, R.：“从躁狂症转变为抑郁症之前尿液中 β-苯乙胺的增加：快速循环仪”

高橋良、仙波純一: 蛋白質 核酸 酵素. 33. 1702-1707 (1988)

Ryo Takahashi，Junichi Senba：蛋白质、核酸、酶。33. 1702-1707 (1988)