Radioallergo sorbent Test For Specific Ig E Antibody To Lidocaine, Procaine. and Methylparaben.

虽然对局部麻醉剂的过敏样反应是众所周知的，但尚未开发用于检测特异性药物反应素（IgE）抗体的放射性过敏吸附试验（RAST）。我们用利多卡因、普鲁卡因和尼泊金甲酯的羧酸衍生物建立了局部麻醉药的RAST。血清样本取自100名对所用药物无过敏反应的志愿者。这些志愿者的RAST阴性值分别为1653 254（SD）cpm（利多卡因）、2750 264 cpm（普鲁卡因）和2805 336 cpm（尼泊金甲酯）。

Although anaphylactoid reactions to local anesthetics are well known, a radio allergosorbent test (RAST) to detect specific drug reagin (IgE) anti-body has not been developed. We established RAST for local anesthetics by using carboxylic acids derivatives of lidocaine, procaine and methylparaben. Serum samples were taken from 100 volunteers who had no allergies to the drugs used. Negative RAST values obtained from these volunteers were 1653 254 (SD) cpm(lidocaine), 2750 264cpm (procaine), and 2805 336cpm(msthylparaben).