THE PULMONARY FUNCTION IN LUNG INJURY INDUCED BY SEVERAL CUSES IN AWAKE SHEEP
几种原因引起的清醒羊肺损伤的肺功能
基本信息
- 批准号:63480209
- 负责人:
- 金额:$ 3.9万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (B)
- 财政年份:1988
- 资助国家:日本
- 起止时间:1988 至 1989
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We studied the changes of pulmonary function such as lung mechanics and the differences of pathophysiology in lung injury induced by several causes in awake sheep. We determined lung mechanics by the following method. Silastic envelopes were placed in the pleural space for the measurement of pleural pressure through a right-sided thoracotomy. A chronictracheo stomy was made. A size 10 Shiley cuffed tracheostomy tube was inserted. Flow and tidal volume (Vt) was measured by a pneumotachograph (Fleish) attached to the tracheostomy tube. Transpulmonary pressure (Ptp) was measured by a differential pressure transducer (Validyne). Dynamic lung compliance (Cdyn) was calculated by dividing Vt by Ptp. Lung resistance(RI.) was calculated by dividing Ptp by flow. We also prepared chronically instrumented sheep to measure the lung lymph dynamics and pulmonary hemodynamics. The responses of the lu ng lymph dynamics and pulmonary hemodynamics to endotoxemia(ETX), pulmonary air embolism(PE), paraquat toxicity(PA) and increased left atrial pressure(IP) are different. ETX, PE and PA produced increased permeability pulmonary edema. ETX and PE produced pulmonary hypertension,though pulmonary hemodynamics in PA did not changes.Lung lymph flow increased 3hr after paraquat. These findings suggest that the development of lung injury in increased permeability pulmonary edema is different according to the cause for lung injury. We compared the changes of lung mechanics in TNF(tumor necrosis factor)-induced lung injury with those in ETX-induced lung injury. In both groups, Cdyn decreased and R_L increased, when pulmonary artery pressure was elevated. These findings suggest that TNF and ETX showed the almost same response to the pulmonary hemodynamics and airway. However, the start of these changes was earlier in TNF group than in ETX group.
我们研究了不同原因引起的清醒绵羊肺损伤后肺力学等肺功能的变化和病理生理的差异。我们用以下方法测定肺力学。通过右侧开胸术,在胸膜间隙放置橡胶包膜,测量胸膜压力。行慢性气管造口术。插入10号雪莉袖口气管造口管。流量和潮气量(Vt)由气管造口管上的气测仪(Fleish)测量。用差压传感器(Validyne)测量肺压(Ptp)。动态肺顺应性(Cdyn)由Vt除以Ptp计算。肺阻力(RI)由Ptp除以流量计算。我们还准备了慢性仪器羊来测量肺淋巴动力学和肺血流动力学。肺淋巴动力学和肺血流动力学对内毒素血症(ETX)、肺空气栓塞(PE)、百草枯中毒(PA)和左房压升高(IP)的反应不同。ETX、PE和PA均导致通透性肺水肿增加。ETX和PE引起肺动脉高压,但PA组肺血流动力学没有改变。百草枯后3小时肺淋巴流量增加。上述结果提示,增透性肺水肿肺损伤的发展过程因肺损伤原因的不同而不同。我们比较了TNF(肿瘤坏死因子)诱导的肺损伤与etx诱导的肺损伤的肺力学变化。两组肺动脉压升高时,Cdyn降低,R_L升高。这些结果表明TNF和ETX对肺血流动力学和气道的反应几乎相同。然而,TNF组比ETX组更早开始这些变化。
项目成果
期刊论文数量(38)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
T.Koizumi他: "Effects of thromboxane synfhase inhibition on TNF (tumor necrosis factor)-induced lung injury in sheep" 1990 Annual Meeting of American Thoracic Society(発表予定). (1990)
T. Koizumi 等人:“血栓素同步抑制对 TNF(肿瘤坏死因子)诱导的绵羊肺损伤的影响”1990 年美国胸科学会年会(待提交)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Shinozaki, S. et.al: "Lung mechanics in TNF(tumor necrosis factor)- and endotoxin-induced lung injury in awake sheep (in press)" 30th Nippon Kyoubu Sikkan Gakkai, 1990.
Shinozaki, S. 等人:“清醒羊中 TNF(肿瘤坏死因子)和内毒素诱导的肺损伤中的肺力学(正在印刷中)”第 30 届日本 Kyoubu Sikkan Gakkai,1990 年。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Koizumi, T. et.al: "Effects of thromboxane synthase inhibition on TNF(tumor necrosis factor)-induced lung injury in sheep (in press)" 1990 Annual Meeting of American Thoracic Society.
Koizumi, T. 等人:“血栓素合酶抑制对 TNF(肿瘤坏死因子)诱导的绵羊肺损伤的影响(正在印刷中)”1990 年美国胸科学会年会。
- DOI:
- 发表时间:
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- 影响因子:0
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KUBO Keishi其他文献
KUBO Keishi的其他文献
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白细胞介素、肿瘤坏死因子-α和蛋白酶在绵羊急性肺损伤发生过程中的作用
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The Study to Clarify The Pathophysiology of Endotoxin-induced Lung Injury -Especially The Role of Tumor Necrosis Factor-
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02807079 - 财政年份:1990
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