Development of Analytical Method of Hemodynamics in Liver Using Radionuclide Tracers

放射性核素示踪剂肝脏血流动力学分析方法的发展

• 批准号: 63480253
• 负责人: HAMAMOTO Ken
• 金额: $ 4.22万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1988
• 资助国家: 日本
• 起止时间: 1988 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63480253/
• 关键词: Hepatic blood flow; Portal blood flow; Xenon-133 washout; Transcatheter arterial embolization; Hepatocellular carcinoma; Liver cirrhosis; Balloon catheter; Expracorporeal measure; 肝動脈血流量; 肝内シャント血流; シンチカメラ; RI動態解析; デコンボリュ-ション解析; ^<99m>TCー標識赤血球

The investigation was undertaken to measure regional potal blood flow of the liver. The measurement was performed by injecting Xenon 133 into proper hepatic artery through a ballooon catheter ans then occluding the proper hepatic artery with an inflated balloon. Data was collected using a gamma camera, and washout curves were generated. They were analyzed by the initial slope method and kety-Schmidt equation. The average regional potal blood flow were : 59.31 <plus-minus> 13.04 ml/100g per min, 58.71 <plus-minus> 14.14 ml/100g per min and 37.12 <plus-minus> 10.11 ml/100g per min in hospital controls, patients with chronic hepatitis and those with liver cirrhosis, respectively. In the patients with liver cirrhosis, the regional potal blood flow was significantly reduced (P 0.01). The reproducibility of this method was satisfactory. The measurement of regional potal blood flow will be useful to evaluate underlying liver injuries and determine indications of a transcatheter arterial embolization of the

本研究旨在测量肝脏局部门静脉血流量。通过球囊导管将氙133注入肝固有动脉，然后用膨胀的球囊闭塞肝固有动脉进行测量。使用伽马照相机收集数据，并生成洗脱曲线。用初始斜率法和kety-Schmidt方程对它们进行了分析。正常对照组、慢性肝炎组和肝硬化组门静脉平均血流量分别为59.31 <plus-minus>± 13.04 ml/100 g/min、58.71 <plus-minus>± 14.14 ml/100 g/min和37.12 <plus-minus>± 10.11 ml/100 g/min。肝硬化患者门静脉局部血流量明显减少（P0.01）.该方法的重现性令人满意。局部门静脉血流量的测量将有助于评估潜在的肝损伤，并确定经导管动脉栓塞的指征。

项目成果

宮内 総一郎他: "Clinical significance of measurement of hepatic blood flow using Xenonー133 and baloon Catheter in patients treatment for hepatocellular carcinoma" European J.Nuclear Medicine. 16. (1991)

Soichiro Miyauchi 等人：“使用 Xenon-133 和球囊导管测量肝血流量在肝细胞癌患者治疗中的临床意义”，欧洲核医学杂志 16。(1991)。

宮内 総一郎 他: "Clinical Slghificance of measurement of hepatic blood flow using Xenonー133 and baloon Catheter in patients treatment for hepatocellular Carcinoma" European J.Nuclear Medicine. 16. (1991)

Soichiro Miyauchi 等人：“使用 Xenon-133 和球囊导管测量肝细胞癌患者肝血流量的临床意义”，欧洲核医学杂志 16。（1991 年）。

Y. Yasuhara, S. Miyauchi, and K. Hamamoto: "A measurement of regional portal blood flow with Xe-133 and balloon catheter in man" EurJ Nucl Med. 15. 346-350 (1989)

Y. Yasuhara、S. Miyauchi 和 K. Hamamoto：“使用 Xe-133 和球囊导管测量人体区域门静脉血流量”EurJ Nucl Med。

安原 美文他: "A measurement of regional portal blood flow with Xeー133 and baloon catheter in man" European J.Nuclear Medicine. 15. 346-350 (1989)

Yoshifumi Yasuhara 等人：“用 Xe-133 和球囊导管测量人体区域门静脉血流量”European J.Nuclear Medicine 15. 346-350 (1989)。

安原 美文 他: "A measurment of regional portal blood flow with Xeー133 and baloon catheter in man" European J. Nuclear Medicine. 15. 346-350 (1989)

Yoshifumi Yasuhara 等人：“用 Xe-133 和球囊导管测量人体区域门静脉血流”，欧洲核医学杂志 15. 346-350 (1989)。