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Analysis on the developmental defects of intra-pelvic muscles and their nerve supplies, in the pig model of ano-rectal malformations.

肛门直肠畸形猪模型盆腔内肌肉及其神经供应发育缺陷分析

基本信息

批准号：
63480287
负责人：
SAWAGUCHI Shigenori
金额：
$ 3.46万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

1) Due to the results of our own establishment of pig model of ano-rectal malformations, we are capable to obtain freely pig material with the anomalies. The maintenance itself of two pig families with ano-rectal malformations is one of the greatest results of this study.2) Using the materials, fundamental studies for the improvement of post-operative bowel motion was scheduled, because the post-operative functional results of high type anorectal malformations were not necessarily good up to the present.3) The propriety of the pig model for simulation of human disease was studied in the first place. Using young adult pig with weight of 30kg, the pelvic organs were dissected to clarify all the routes of sacral plexus and pudendal plexus down to the very peripheries, with intrapelvic muscle dissections. The similarities and differences were studied according to the textbooks of human anatomy. Muscles and plexi were all similar to human, except the absence of the pubo-rectal muscle sling … More in the adult pig. The adequacy of the pig material as model study material was confirmed.4) l Studies on the morphology of pudendal plexus and nerve supply to intrapelvic muscles: Eight sides including 2 male and female normal pig and 2 male and femalk pigs with ano-rectal malformations were studied. All the details of nerve route were clarified by the classical dissection technique. Most of the material were adult, but partly neonatal materials were used for supplement of the adult material in the recent stage. In the anomalous pig, the external sphincter was very scanty or lacking. There was no nerve supply to the external sphincter in the case without this muscle.Otherwise all the nerve supplies were quite normal.5) Studies on the intrapelvic autosomal nerve supply: Six sides, including one normal male and female, and two anomalous male and female materials were studied. There were no abnormalities in the ano-rectal malformations. According to the size of the materials, the autosomal nerves was observed to grow in size and volume. The factor of growth of the nerve system is one of the next study purpose. Less

1)由于我们自己建立的猪肛门直肠畸形模型的结果，我们能够自由地获得具有异常的猪材料。两个患有肛门直肠畸形的猪家族的维持本身是本研究的最大结果之一。2）使用这些材料，计划进行改善术后肠运动的基础研究，由于高位型肛门直肠畸形的术后功能效果至今不一定好。首先研究了猪模型用于模拟人类疾病的适宜性。用30kg的青年猪，解剖盆腔器官，明确骶丛和阴部丛的所有走行，并解剖盆腔内肌肉。以人体解剖学教材为参照，研究其异同。肌肉和神经丛均与人类相似，除了没有耻骨直肠肌吊带 ...更多信息在成年猪身上。4）1阴部神经丛的形态及盆内肌的神经支配研究：正常猪2只，肛门直肠畸形猪2只，雌雄各半。通过经典的解剖技术，明确了神经走行的所有细节。材料以成体材料为主，但也有部分新生材料用于补充成体材料。在异常的猪，外括约肌是非常稀少或缺乏。5）骨盆内常染色体神经分布的研究：共6侧，包括正常男女各1侧，异常男女各2侧。肛门直肠畸形无异常。根据材料的大小，观察到常染色体神经的大小和体积不断增长。神经系统的生长因子是今后的研究方向之一。少