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Evaluation on the animal rooms with one way air-flow system.

单向气流系统动物房的评价。

基本信息

批准号：
63480484
负责人：
YAMAUCHI Chuhei
金额：
$ 3.01万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63480484/
关键词：
Laboratory Animals Animal Rooms Air Current Airborne Dust Particles Ammonia Airborne Bacteria Allergy Allergen アレルゲン環境ラット

项目摘要

We carried out a large survey on Laboratory Animal Allergy (LAA) in Japan 1987.1304 of the subjects, 23% had one or more allergic symptoms such as nasal, eyes, respiratory and skin symptoms.As a example for the prevention of LAA, we developed an animal room with a one way air- flow system.This study have practically evaluated the environmental conditions of various animal rooms which are reconstructed from conventional turbulent air flow system to one way air-flow system.It was certified that the air in rooms flowed out directly from working area throughout the rack or cage to exhaust side. Static pressure in racks or cages are about 0.5 mmH_2O higher than exhaust side. Mean air velocity are 0.16m/sec at the holes of sliding door in front of the racks, 2.2m/sec at the holes of behind of the racks. Mean ventilation rate was 10.5 times/hr for the rooms, 92.7 times/hr for the cages. Temperature and humidity in the working area in rooms were the range of 20 -26ﾟC, 51- 69%, and they were slightly increased inside of the rack or cage. The number of airborne bacteria, airborne dust particle and ammonia in the working area in rooms decreased markedly than those before the reconstruction. Protein in the airborne dust in the working area was not detected. 83% of LAA subjects which developed LAA symptoms in animal rooms with turbulent air-flow systems became weak in the rooms with one way air-flow systems. Also, one way air-flow system created more comfortable environments for animals Serological monitoring for HVJ, MHV and M. plumonis in mice were negative for 12 months and these mice also showed no infectious finding their autopsy.From the above results, we conclude that the animal room with one way air-flow systems serve to make comfortable environments for both the animals and the workers.

我们于1987年在日本进行了一项关于实验动物过敏（LAA）的大型调查。在1304名受试者中，23%的受试者有一种或多种过敏症状，如鼻、眼、呼吸道和皮肤症状。我们开发了一个单向通风的动物房本研究对由传统的湍流式气流系统改造为单向气流系统的各种动物房的环境条件进行了实际评价，经验证，室内空气直接从工作区流出，通过机架或笼架流向排气侧。机架或笼内的静压比排气侧高0.5mmH_2O左右。货架前拉门孔处平均风速为0.16米/秒，货架后拉门孔处平均风速为2.2米/秒。房间的平均通风率为10.5次/小时，笼舍的平均通风率为92.7次/小时。室内工作区的温度和湿度范围为20 - 26 ℃，51- 69%，机架或笼内的温度和湿度略有增加。改造后房间工作区空气中细菌、尘埃粒子和氨含量较改造前明显下降。作业区空气中粉尘蛋白质未检出。83%的LAA受试者在具有湍流气流系统的动物房中出现LAA症状，在具有单向气流系统的动物房中变得虚弱。单向气流系统为动物创造了更舒适的环境。结果表明，采用单向通风系统的动物房能为动物和工作人员提供舒适的环境。