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批准号:
04650760
负责人:
KATOH Akira
金额:
$0.7万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1992
资助国家:
日本
项目状态:
已结题
起止时间:
1992 至 1993
中文摘要
近年来,仿生化学受到了广泛的关注。这种化学的目的是用化学方法模拟生物体的复杂功能。在本研究中,我研究了基于l -酪氨酸的新型肽磷脂的合成及其功能评价。得到了以下结果:1. 在l -酪氨酸的适当保护下制备了Boc-Tyr(OBzl)-OTce(a)。2. Boc-Tyr(OCH_2CO_2Bzl)-OTce(b)由Boc-Tyr-OTce的苯氧羰基甲基化反应得到。3. (b)在二氧六烷中用4N或在氢气氛下用Pd-C处理得到H-Tyr(OCH_2CO_2Bzl)- oce (c)或Boc-Tyr(OCH_2CO_2H)- oce (d)。4. (c)和(d)通过wsc -加成法偶联得到二肽(e)。(e)以与4.6相同的方式转化为四肽(f)。采用高稀释法合成所需肽素(g)。7. (g)在DMSO溶液中未表现出特异性强氢键。由于我花了很长时间来合成我想要的肽素,所以它的功能还不能完全表征。
英文摘要
Recently, the biomimetic chemistry has been paid much attention. The aim of this chemistry is to mimic chemically the sophisticated functions of organisms.In this research, I investigated the synthesis of L-tyroshin-based new peptidephane ant its function evaluation.The following results were obtained. 1. Boc-Tyr(OBzl)-OTce(a) was prepared by the appropriate protection of L-tyrosine. 2. Boc-Tyr(OCH_2CO_2Bzl)-OTce(b) was obtained by the benzyloxycarbonylmenthylation of Boc-Tyr-OTce. 3. Treatment of (b) with 4N in dioxane or with Pd-C under hydrogen atmosphere afforded H-Tyr(OCH_2CO_2Bzl)-OTce(c) or Boc-Tyr(OCH_2CO_2H)-OTce(d). 4. The coupling of (c) and (d) by the WSC-additive method gave the dipeptide (e). 5. (e) was converted into the tetrapeptide (f) in the same fashion as 4.6. The desired peptidephane (g) was synthesized using the high dilution method. 7. (g) did not show the specific strong hydrogen bond in DMSO solution.Since I spent a long time to synthesize the desired peptidephane, the function of it could not be fully characterized.
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加藤,明良: "修飾チロシンを基本骨格とした新規ペプチドファンの合成" 日本化学会第65春季年会講演予稿集. 2. 524 (1993)
Kato, Akira:“使用修饰酪氨酸作为基本骨架的新型肽范的合成”日本化学会第 65 届春季年会论文集(1993 年)。
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加藤 明良: "チロシンの化学修飾による新規ペプチドファン合成の試み" 日本化学会第64秋季年会講演予稿集. 2. 808 (1992)
加藤彰:“尝试通过酪氨酸的化学修饰合成新型肽扇”日本化学会第 64 届秋季年会论文集 2. 808 (1992)。
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加藤 明良: "修飾チロシンを基本骨格とした新規ペプチドファンの合成" 日本化学会第65春季年会講演予稿集. 2. 524 (1993)
加藤彰:“以修饰酪氨酸为基本骨架的新型肽范的合成”日本化学会第 65 届春季年会论文集 2. 524 (1993)。
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Akira katoh,Junko Ohkanda,Keiryo Mitsuhashi: "N-Hydroxyamide-containing Heterocycles.New Effective Additives for Peptide synthesis by the Dicyclohexyl-Carbodiimide Method" Chemistry Letters. 2009-2012 (1992)
Akira katoh、Junko Ohkanda、Keiryo Mitsuhashi:“含 N-羟基酰胺的杂环。二环己基碳二亚胺法合成肽的新型有效添加剂”化学快报。
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Akira Katoh, Sadamitsu Jyumonji, Junko Ohkanda, Keiryo Mitsuhashi: "An Atempt to Synthesize a New Peptidephane by the Chemical Modification of Tyroshine" Abstracts of 64th Autumn Meeting of the Chemical Society of Japan. No ll. 808 (1992)
Akira Katoh、Sadamitsu Jyumonji、Junko Ohkanda、Keiryo Mitsuhashi:“通过酪氨酸化学修饰合成新肽的尝试”日本化学会第 64 届秋季会议摘要。
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共 7 条
Influences of stresses to motor learning
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批准号:16K01603
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2016
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负责人:KATOH Akira
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依托单位:
Evaluation of novel heterocycle-containing iron(III) removal agents as promoting agents for photodynamic therapy efficiency
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批准号:19590014
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.16万
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财政年份:2007
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负责人:KATOH Akira
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依托单位:
Studies on Novel Syntheses of Fluorecent Tripodal Hexadentate Iigands and Than Application to fluorescent Probes for Microscopic Observation of Cells
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批准号:15550152
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2003
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负责人:KATOH Akira
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依托单位:
Studies on Development of High-sensitive Optical Purity Determination Reagents Using Optically Active Fluorescent Quinoxalines
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批准号:11650876
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
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财政年份:1999
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负责人:KATOH Akira
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依托单位:
A Novel Synthesis of Bipyridine-Containing Hybrid Compounds Directed High Efficiency of the Electron Transfer and Their Functional Evaluation
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批准号:09650943
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
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财政年份:1997
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负责人:KATOH Akira
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依托单位:
Development of New Fluorescence Derivatization Reagents with 6-Aminoquinoxalines
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批准号:07651038
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.34万
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财政年份:1995
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负责人:KATOH Akira
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依托单位:
A Systematic study on Traffic Flow Theory and Network Planning Procedure
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批准号:61302064
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项目类别:Grant-in-Aid for Co-operative Research (A)
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资助金额:$5.76万
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财政年份:1986
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负责人:KATOH Akira
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依托单位:
海外基金