Exploring obesity with respect to the mTOR pathway and its regulating micro-RNAs and to epigenetic changes in the methylation pattern of obesity associated genes

探索肥胖与 mTOR 通路及其调节 micro-RNA 以及肥胖相关基因甲基化模式的表观遗传变化的关系

• 批准号: 441645438
• 负责人: Dr. Sebastian Holländer
• 金额: --
• 依托单位: Klinik für Allgemeine Chirurgie, Viszeral-, Gefäß- und Kinderchirurgie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/441645438?language=en
• 关键词: Exploring; obesity; respect; mTOR; pathway

Obesity is currently considered a chronic disease attended by increased morbidity and mortality risk. As obesity is frequently associated with diabetes mellitus type 2 and metabolic syndrome, we plan to explore the role of the mTOR pathway and its regulating micro-RNA miR-496 with respect to the obesity disease in this application. According to the current state of knowledge, innate and also acquired changes of DNA impact widely variance of body weight. Since an aberrant methylation pattern was already demonstrated in obese patients compared to volunteers with normal weight we also plan to study epigenetic changes associated with the development of obesity. In conclusion, we aim to investigate the cause and development of the obesity disease with respect to the mTOR pathway and its regulating micro-RNA miR-496 and to investigate epigenetic changes in the methylation pattern of obesity associated genes.

肥胖目前被认为是一种慢性疾病，其发病率和死亡风险增加。由于肥胖经常与2型糖尿病和代谢综合征相关，因此我们计划在本申请中探讨mTOR通路及其调节微小RNA miR-496在肥胖疾病中的作用。根据目前的了解，先天的和后天的DNA变化对体重的变化影响很大。由于与体重正常的志愿者相比，肥胖患者已经证明了异常的甲基化模式，因此我们还计划研究与肥胖发展相关的表观遗传变化。总之，我们的目标是通过 mTOR 通路及其调节微小 RNA miR-496 来研究肥胖疾病的病因和发展，并研究肥胖相关基因甲基化模式的表观遗传变化。