Preventing obesity through Biologically and bEhaviorally Tailored inTERventions for you | BETTER4U

BETTER 4U旨在识别和个性化管理所有体重增加的决定因素，通过同质的，全球适应性的和实际评估的公共卫生举措和关键干预措施，对抗日益增加的超重/肥胖人数。该项目将以以往的重点项目和生物库为基础，重点关注迄今为止被忽视的体重增加的多基因背景对超重/肥胖人群体重管理生活方式干预措施有效性的影响。BETTER 4U旨在探讨全球肥胖挑战，研究问题，并在现代人工智能技术的帮助下，通过世界各地专家的贡献，以切实可行的方式提供解决方案。BETTER 4U将通过以下目标实现：1.通过荟萃分析（来自超过50项研究，超过100万人的BETTER 4U数据）和广泛的文献荟萃审查，全面了解和解读与整个生命过程中体重增加相关的遗传学，代谢组学，微生物群，社会经济，地理，文化和生活方式特征。2.基于肥胖决定因素的因果AI模型和7个欧洲国家的试点研究，开发预防体重增加的BETTER 4U干预方法。3.部署技术辅助的实时监测工具，以测量详细的行为指标及其与环境背景的关系。4.在一项对照、随机临床试验中，根据个人定制的生活方式改变建议，评估新型BETTER 4U干预方法的有效性。5.通过识别实施障碍和促进因素，以及评估参与者和利益相关者的实施结果，最大限度地提高BETTER 4U干预方法的可移植性和适用性。6.采用以人为本的可持续护理方法，制定和传播BETTER 4U肥胖预防干预方法指南。

BETTER4U aims at the identification and personalized management of all weight gain determinants to battle the increasingly rising numbers of overweight/obesity, via homogenous, globally adaptable and practically assessed public health initiatives and key interventions. Building on previous key projects and biobanks, the project will focus on the hitherto neglected impact of the polygenic background of weight gain on the effectiveness of lifestyle interventions for weight management in people with overweight/obesity. BETTER4U aims to probe into the global obesity challenge, study the problem and offer solutions in a tangible realistic way with the assistance of modern AI technologies and the contribution of experts around the world. BETTER4U will be realized through the following objectives: 1. To comprehensively understand and decipher genetics, metabolomics, microbiota,socio-economic, geographical, cultural and lifestyle features linked to weight gain throughout the life course, via meta-analyses (BETTER4U data from >50 studies, >1 million individuals) and extensive literature meta-review. 2.To develop the BETTER4U intervention methodology for weight gain prevention, based on a causal AI model of obesity determinants and a pilot study in 7 European countries. 3.To deploy technologyassisted, real-time monitoring toolsto measure detailed behavioral indicators and their relation to the environmental context. 4.To evaluate the efficacy of the novel BETTER4U intervention methodology in a controlled, randomized clinical trial, based on individually-tailored recommendations for lifestyle change. 5.To maximize transferability and applicability of the BETTER4U intervention methodology by identifying implementation barriers and facilitators, as well as to evaluate implementation outcomes in both participants and stakeholders. 6. To develop and disseminate the BETTER4Uobesity prevention intervention methodology guidelines using a peoplecentred, sustainable care approach.